Minerva School on Pharmacogenetics:
Improving the safety and efficacy of medicines
Tel-Aviv University,
Tel-Aviv , Israel
June 21-24, 2009
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OrganizersGregory Livshits,
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Pharmacogenetics offers a potential for improved
healthcare through safer and more effective medicines and personalized drug and
dosage choices. This Minerva
School will offer
students an updated look on current knowledge on pharmacogenetics,
as well as on current obstacles and challenges which delay the clinical uptake
of pharmacogenetics.
Sackler
Faculty of Medicine, Tel-Aviv
Dates
21 – 24 June, 2009
Confirmed Speakers (alphabetized) Juliane Bolbrinker,
Charite Jurgen Brockmoller,
Ingolf Cascorbi,
University Felix Frueh,
Medco Health Inc. USA Uwe Fuhr, David Gurwitz,
Tel-Aviv University, Israel David Karasik,
Harvard University,
Daniel Kurnik,
Julia Kirchheiner,
Klaus Lindpaintner,
Roche Diagnostics, Ariel Miller, Catherine Payne, Gideon Rechavi, Tel-Aviv University, Israel Amnon Shabo, IBM labs, Haifa, Israel Noam Shomron,
Timothy Spector, King’s College Matthias Schwab, Andre Uitterlinden,
Erasmus Medical
Center, Registration is FREE OF CHARGE and open till
May 25, 2009 by writing to the Minerva
School secretariat, Gilad Silberberg. Abstract submission instructions Posters are welcomed and
would be presented on display boards (about 120X120 cm) during the entire Those wishing to present
posters as short talks (15 min including discussion) during the oral sessions
(June 21 & 22 afternoons) are welcomed to contact one of the organizers and
send their abstracts (up to 400 words). Slots will be assigned according to
order of requests until filled. Sunday, June 21 First Session: The
Science of Pharmacogenetics 09:30 Greetings
(Dean, Organizers) 09:45 Klaus Lindpaintner, Roche Diagnostics Clinical
utilization of Pharmacogenetics 11:00 Coffee 11:20 Felix Frueh, Medco Health Inc. 12:20 Julia Kirchheiner, University
of Ulm Pharmacogenetic study design 13:20 Lunch 15:00 David Gurwitz, TAU Pharmacogenetics: Setting the priorities 16:00 Amnon
Shabo, IBM labs, The
importance of electronic health records for pharmacogenetics 17:00 Coffee 17:15 Poster session I Marja Susanna Leskela, Spanish National Cancer Research Center
Pharmacogenomics in the post-marketing environment: how pharmacies can make a difference
Daniela Caronia, Spanish National Cancer Research Center
Common variations in cytidine deaminse promoter are associated with hand-foot syndrome in Capecitabine-treated breast and colorectal cancer patients
Luis Javier Leandro, Spanish National Cancer Research Center
Expression and regulation of beta-tubulin isotypes: relevance for taxane response
Monday, June 22
Second Session: Pharmacogenetics in Oncology
09:00
Jurgen
Brockmoller,
Pharmacogenetics of anti-cancer drugs
10:00
The contribution of RNA editing to human trascriptome and proteome variations
11:00
Coffee
11:20
Pharmacogenomics lessons from the success story of childhood leukemia therapies
12:20
Jurgen
Brockmoller,
Renal transporter pharmacogenetics
13:20
Lunch
Third Session: Clinical Pharmacogenetics
15:00
Tim Spector, KCL
Twin studies in pharmacogenetics
16:00
Poster session II
Hava Peretz, Tel Aviv Sourasky Medical Center
Translating into clinical practice the complexity of thiopurine pharmacogenetics.
Angela Seeringer, University of Ulm
Influence of genetic variants on therapeutic outcome in patients with Diabetes mellitus Type 2 treated with oral antidiabetics
Sumit Parmar, University of Ulm
Ex vivo assessment of between-subject variability in cytarabine toxicity: role of genetic factors
17:00
Coffee
17:15
Poster session III
Sandra Lächelt, University of Kiel
Influence of ABCC2 haplotypes on gene expression
Eleonora Turrini, University of Kiel
Influence of genetic variants and post-transcriptional factors on Imatinib transporters as determinants of the pharmacological response
Mladen Tzvetkov, University of Göttingen
Pharmacogenetics of therapy response in Non-Hodgkin Lymphoma: Polymorphism in matrix metalloproteinase 2 predicts patients survival
Tuesday, June 23
Third Session: Clinical Pharmacogenetics (cont.)
09:00
Julia Kirchheiner, University of Ulm
Pharmacogenetics of antidepressant drug treatment
10:00
Pharmacogenetics of antithrombotic therapies
11:00
Coffee
11:20
Juliane
Bolbrinker, Charite University
Medicine,
Pharmacogenetics of immune suppression following organ transplantation
12:20
Noam Shomron, TAU
miRNA: master switches of cell regulation
13:20
Lunch
15:00
Ingolf
Cascorbi, University
Pharmacogenetics in treatment of atherosclerosis and hypertension
16:00
Andre Uitterlinden, Erasmus University
Genome-wide studies in pharmacogenetics
17:00
Coffee
17:20
Nili Avidan, Technion
Pharmacogenetics of treating autoimmune diseases
Wednesday, June 24
Fourth Session: Improving Drug Safety with Pharmacogenetics Tools
09:00
Uwe Fuhr, University of Koln
Phenotype or genotype: trait and state markers in drug metabolism
10:00
Uwe Fuhr, University of Koln
Drug-drug interactions and genotypes
11:00
Coffee
11:20
Catherine Payne, Manchester University
Applying an economic framework to the evaluation and valuation of pharmacogenetic tests
12:20
Catherine Payne, Manchester University
13:20
Lunch
15:00
Matthias Schwab, University of Stuttgart
Developmental pharmacogenetics: which polymorphisms matter during early childhood?
16:00
Round Table: how can we accelerate the clinical uptake of pharmacogenetics?
17:00
Close of
Genetics and Pharmacogenetics of Bone and Skeletal Disorders
A one-day international symposium on “Genetics and Pharmacogenetics of Bone and Skeletal Disorders” will be held on June 25 2009, immediately following this Minerva School at the same location. The symposium programme is available here.
Accommodation
Participants will be
accommodated at the Tel-Aviv Tal
Hotel.
The hotel offers the
Single rooms will be offered for invited speakers. Invited students will be accommodated two per room and are encouraged to choose their roommates and report their choices to the organizers.
The hotel offers free Wi-Fi or line internet access which is available in all rooms.
Free Wi-Fi access is also available at the Minerva School location.
Rooms include coffee and tea facilities, a mini-fridge and safe. Free cable TV is also available and includes a choice of international channels.
The hotel is located just
one minute walk from one of the most popular Tel-Aviv beaches. If you wish to
swim be careful to follow the instructions of the lifesaver. Swimming outside the
permitted areas and when there is no lifeguard on duty is a punishable felony
in
Free transportation to
Free transportation from the Ben-Gurion Tel-Aviv airport will be provided for invited speakers and invited students. A driver will be welcoming you at the airport arrivals hall with a sign saying “MINERVA - Tel-Aviv University”. The ride to Tel-Aviv takes from 30 to 50 min depending on time of day.
Other participants may arrange for a similar transportation to the hotel for a fee of US$55 which will be paid directly to the driver. A taxi would typically cost about US$30 but bear in mind that lines for taxis could sometimes be long.
The hotel is located near
the old Tel-Aviv
Further information on Tel-Aviv tourism is available from the Tel-Aviv Municipality Tourism.
Information for invited speakers
Please prepare your talks (in English) aiming at the graduate student audience. Please keep in mind that your talks are intended as instructive lectures and not as reports about your own latest research findings. You may however dedicate the last 5 to 10 min of your talk to your own research projects.
Talks should last up 1 h which must allow at least 15 min for discussion.
The organizers will greatly appreciate if you are kindly willing to contribute your teaching slides to this website, which will remain active after the school and will feature links to contributed slides files.
Group photo of speakers and guest students taken on June 23, 2009
We thank the following for their kind support: Minerva Foundation, The Yoran Institute for Human Genome Research, Sackler Faculty of Medicine, Tel-Aviv University, Roche Diagnostics, Pronto Diagnostics and National Laboratory for Genetics of Israeli Populations.
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