Selected Publications
Finkeltov, I., Kuhn, S., Glaser, T., Idelman, G., Wright, J.J., Roberts, C.T., Jr. and Werner, H. (2002) Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein. Oncogene, in press.
LeRoith, D. and Werner, H. (2002) Insulin like growth factors. In: Encyclopedia of Cancer, ed. by Bertino, J.R., Academic Press, San Diego, Second Edition. In press.
Ayalon, D., Glaser, T. and Werner, H. (2001) Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein. Growth Hormone & IGF Res. 11:289-297.
Shalita-Chesner, M., Katz, J., Shemer, J. and Werner, H. (2001) Regulation of insulin-like growth factor-I receptor gene expression by tumor necrosis factor-a and interferon-g. Mol. Cell. Endocrinol. 176:1-12.
Werner, H., Ooh, Y. and Roberts, Jr., C.T. (2001) Apoptosis in breast cancer. In: Programmed Cell Death: Role in Disease Pathogenesis and Prevention, ed. by Mattson, M.P., Estus, S. and Rangnekar, V., Elsevier Sciences, Amsterdam, pp. 1-22.
Werner, H., Shalita-Chesner, M., Abramovitch, S., Idelman, G., Shaharabani-Gargir, L. and Glaser, T. (2000) Regulation of the IGF-I receptor gene by oncogenes and antioncogenes: implications in human cancer. Mol. Gen. Metab. 71:315-320.
Maor, S.B., Abramovitch, S., Erdos, M., Brody, L.C. and Werner, H. (2000) BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1. Mol. Gen. & Metab., 69:130-136.
Werner, H. and LeRoith, D. (2000) New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cell. Mol. Life Sciences 57:932-942.
LeRoith, D., Blakesley, V. and Werner, H. (1999) Molecular mechanisms of insulin-like growth factor I receptor function: implications for normal physiology and pathological states. In: Handbook of Physiology, Section 7: The Endocrine System, Vol. V: Hormonal Control of Growth, ed. by Kostyo, J.L., Oxford University Press, pp. 633-662.
Werner, H. (1999) Molecular biology of the Type 1 IGF receptor. In: The IGF System: Molecular Biology, Physiology and Clinical Applications, ed. by Rosenfeld, R.G. and Roberts, C.T., Jr., Contemporary Endocrinology Series, Humana Press, Totowa, New Jersey, pp. 63-88.
Ohlsson, C., Kley, N., Werner, H. and LeRoith, D. (1998) p53 regulates IGF-I receptor expression and IGF-I induced tyrosine phosphorylation in an osteosarcoma cell line: Interaction between p53 and Sp1. Endocrinology 139:1101-1107.
Werner, H. (1998) Dysregulation of the Type 1 IGF receptor as a paradigm in tumor progression. Mol. Cell. Endocrinol. 141:1-5.
Hernandez-Sanchez, C., Werner, H., Roberts, Jr., C.T., Woo, E.J., Hum, D.W., Rosenthal, S.M. and LeRoith, D. (1997) Differential regulation of insulin-like growth factor I (IGF-I) receptor gene expression by IGF-I and basic fibroblast growth factor . J. Biol. Chem. 272:4663-4670.
Werner, H. and LeRoith, D. (1997) The insulin-like growth factor I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis. Crit. Rev. Oncogenesis 8:71-92.
Werner, H. and LeRoith, D. (1996) The role of the insulin-like growth factor system in human cancer. In: Advances in Cancer Research, ed. by Vande Woude, G.F. and Klein, G., Academic Press, San Diego, Vol. 68, pp. 183-223.
Karnieli, E., Werner, H., Rauscher, F.J., III, Benjamin, L. and LeRoith, D. (1996) The IGF-I receptor gene promoter is a molecular target for the Ewings' sarcoma/ Wilms' tumor 1 fusion protein. J. Biol. Chem. 271:19304-19309.
Werner, H., Karnieli, E., Rauscher, F.J., III and LeRoith, D. (1996) Wild type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc. Natl. Acad. Sci. USA 93:8318-8323.
Werner, H., Shen-Orr, Z., Rauscher, F.J., III, Morris, J., Roberts, Jr., C.T. and LeRoith, D. (1995) Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression. Mol. Cell. Biol. 15:3516-3522.
Werner, H., Rauscher, F.J., III, Sukhatme, V.P., Drummond, I.A., Roberts, Jr., C.T. and LeRoith, D. (1994) Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site. J. Biol. Chem. 269:12577-12582.
Werner, H., Re, G.G., Drummond, I.A., Sukhatme, V.P., Rauscher, III, F.J., Sens, D.A., Garvin, A.J., LeRoith, D. and Roberts, Jr., C.T. (1993) Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms' tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms' tumor gene product. Proc. Natl. Acad. Sci. USA 90:5828-5832.
Additional publications: PUBMED
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