Program

Tuesday, June 25

18:00 - 20:00 - Registration - Main Entrance Hall

19:30 - Informal Get-Together - Terrace

Wednesday June 26

08:30 - Opening and Greetings

Isaac P. Witz, Tel Aviv University, Tel Aviv, Israel

Peter A. Czernilofsky, Boehringer Ingelheim Austria, Vienna, Austria

Norbert Kraut, Boehringer Ingelheim Austria, Vienna, Austria

Plenary Session I - Signaling and Control of Gene Expression (I)

Chairperson: P. Czernilofsky

09:00 U. Rapp, Würzburg, Germany

Progression, Therapy and Prevention of raf induced lung cancer in mice

09:25 Y. Ben-Neriah, Jerusalem, Israel

NF-KAPPA B ACTIVATION IN CANCER: HUMAN TUMORS AND ANIMAL MODELS

09:50 A. Bardelli, Baltimore, MD, USA

A PHOSPHATASE ASSOCIATED WITH METASTASIS OF COLORECTAL CANCER

10:10 S. Yaccoby, Little Rock, AR, USA

TUMOR - MICROENVIRONMENT INTERACTION MODULATES GENE EXPRESSION IN MULTIPLE MYELOMA

10:30 – Coffee

Special Lecture - Introduction by I. Witz

11:00 P.H. Krammer, Heidelberg, Germany

IMMUNE ATTACK VS TUMOR ATTACK

Plenary Session I - Signaling and Control of Gene Expression (II)

11:40 L. Huber, Vienna, Austria

EGF RECEPTOR SIGNALING REQUIRES SCAFFOLDING OF MAP KINASE ON LATE ENDOSOMES

12:05 M. Bar-Eli, Houston, TX, USA

GENE REGULATION IN MELANOMA PROGRESSION:

TUMOR-MICROENVIRONMENT ASSOCIATION

12:25 B. Sredni, Ramat Gan, Israel

INHIBITION OF B16 MELANOMA AND GLIOMA BY AS101 VIA RAS DEPENDENT DOWNREGULATION OF IL-10

12:50 – Lunch

Plenary Session II - Tumor-Endothelium Interactions (I)

Chairperson: E. Yefenof

14:00 K. Alitalo, Helsinki, Finland

GROWTH FACTOR REGULATION OF LYMPHANGIOGENESIS AND METASTASIS

14:25 J.A. Varner, San Diego, CA, USA

REGULATION OF ANGIOGENESIS BY INTEGRIN MEDIATED SIGNAL TRANSDUCTION

14:50 E. Keshet, Jerusalem, Israel

NEW INSIGHTS INTO NEOVASCULARIZATION IN THE ADULT

15:15 R. Pasqualini, Houston, TX, USA

MAPPING VASCULAR DIVERSITY BY SCREENING PEPTIDE LIBRARIES

15:40 C. Kieda, Orléans, France

ENDOTHELIAL CELLS DISTINCTIVE SIGNAL MOLECULES FOR ADHESION AND SELECTIVE TISSUE INVASION BY CIRCULATING CELLS

16:00 – Coffee

Plenary Session II - Tumor-Endothelium Interactions (II)

Chairperson: B. Sredni

16:30 R. Lupu, Berkeley, CA, USA

INVOLVEMENT OF CYR61, AN ANGIOGENIC FACTOR, IN BREAST CANCER TUMOR PROGRESSION

16:50 G. Neufeld, Haifa, Israel

THE NEUROPILINS: SPLICE VARIANT SPECIFIC VEGF CO-RECEPTORS THAT ARE DIFFERENTIALLY EXPRESSED IN ARTERIES AND VEINS

Plenary Session III - Microenvironment-Control of Cell Cycle and Apoptosis

Chairperson: B. Sredni

17:10 H. Lorberboum-Galski, Jerusalem, Israel

A NOVEL APPROACH OF UTILIZING APOPTOSIS FOR CANCER THERAPY

17:30 G. Bauer, Freiburg, Germany

SELECTIVE APOPTOSIS INDUCTION IN TRANSFORMED CELLS THROUGH REACTIVE OXYGEN AND NITROGEN SPECIES: A POTENTIAL CONTROL STEP DURING TUMOR FORMATION

20:00 - Conference Dinner – Congress Casino Baden

Thursday June 27

Plenary Session IV - Adhesion and Adhesion Molecules (I)

Chairperson: D. Zipori

08:45 G. Christofori, Basel, Switzerland

CELL ADHESION, TUMOR INVASION, AND METASTASIS

09:10 D. Sheppard, San Francisco, CA, USA

DIVERSE ROLES OF THE EPITHELIAL INTEGRIN, AVB6, IN THE DEVELOPMENT AND PROGRESSION OF EPITHELIAL TUMORS

09:35 D. Radisky, Berkeley, CA, USA

MATRIX-METALLOPROTEINASE-INDUCED MALIGNANCY IN MOUSE MAMMARY EPITHELIAL CELLS

9:55 – Coffee

Special Lecture - Introduction by I. Witz

10:30 R.C. Gallo, Baltimore, MD, USA

The Microenvironment of Aids-associated malignancies - hiv, hhv8 and cytokines

Plenary Session IV - Adhesion and Adhesion Molecules (II)

Chairperson: E. Tahara

11:10 D. Breitkreuz, Heidelberg, Germany

ALTERED CELL-MATRIX INTERACTIONS OF MALIGNANT HUMAN HACAT-RAS CELLS IN NUDE MOUSE GRAFTS

11:30 H. Beug, Vienna, Austria

INTEGRATION OF RECEPTOR SERINE- AND TYROSINE KINASE SIGNALS IN EPITHELIAL PLASTICITY AND METASTASIS

11:50 S. Dedhar, Vancouver, Canada

INTEGRIN LINKED KINASE AND CANCER PROGRESSION

Plenary Session V - Novel Approaches for Cancer Therapy

Chairperson: I. Vlodavsky

12:10 P. Bohlen, New York, NY, USA

Vascular targets for anti-cancer therapy using monoclonal antibodies

12:35 Gert Riethmüller, München, Germany

IMMUNOTHERAPY OF MINIMAL RESIDUAL CANCER: TRIALS AND TRIBULATIONS WITH

AN ELUSIVE TARGET

13:00 – Lunch

14:15 – 16:00

Minisymposium I - Tumor-Stroma Interactions: Adhesion and its Regulation

Chairperson: E. Yefenof

M. Willhauck, Heidelberg, Germany

Control of tumor phenotype by stromal modulation

S. A. Lelièvre, West Lafayette, IN, USA

NuMA functionally links cell adhesion and nuclear structure to regulate cell survival in breast

Z. Qin, Berlin, Germany

TUMOR REJECTION BY DISTURBING TUMOR STROMA CELL INTERACTIONS

J. A. Engbring, Bethesda, MD, USA

A METASTASIS-PROMOTING SITE ON LAMININ-1 BINDS A HEPARAN SULFATE/CHONDROITIN SULFATE-CONTAINING PROTEOGLYCAN ON B16-F10 MELANOMA CELLS

J.F. Marshall, London, UK

The C-terminal 11 amino-acids of the b6 integrin subunit are required for invasion by squamous cell carcinoma cells

I. Yron, Tel Aviv, Israel

THE FOCAL ADHESION KINASE (P125^FAK) IS CONSTITUTIVELY ACTIVE IN HUMAN MALIGNANT MELANOMA

M. Parsons, Manchester, UK

Site-directed perturbation of PKC-integrin interaction blocks breast carcinoma cell chemotaxis

J. E. Koblinski, Bethesda, MD, USA

BREAST AND PROSTATE CANCER CELL ADHESION TO OSTEONECTIN INVOLVES SYNERGY WITH FIBRONECTIN AND a5b1 INTEGRIN

14:15 – 16:00

Minisymposium II - Novel Approaches for Therapy

Chairperson: B. Sredni

I. Raineri, Basel, Switzerland

Suppression of AU-Binding Proteins with Small Inhibitory RNAs (siRNAs) Modulates Expression of ARE Containing Growth Regulators

L.M. Ching, Auckland, New Zealand

NFkB ACTIVATION IN TUMORS BY THE ANTI-VASCULAR AGENT DMXAA DOES NOT INDUCE RESISTANCE TO THERAPY

J. M. Yingling, Indianapolis, IN, USA

SMALL MOLECULE TGF-b RECEPTOR INHIBITORS ELUCIDATE A DIFFERENTIAL REQUIREMENT FOR TYPE I RECEPTOR ACTIVITY IN MEDIATING DOWNSTREAM SIGNALS

D. Bisacchi, Genova, Italy

Novel inhibitors of metalloproteases and angiogenesis, new uses for “Old” drugs

U. Stenram, Lund, Sweden

HEAT SHOCK PROTEIN 70 (HSP70) IN INTERSTITIAL LASER THERMOTHERAPY (ILT) OF A CARCINOMA IMPLANTED INTO RAT LIVER

M. Koch, Pecs, Hungary

Expression studies on the novel tumor marker PIBF

A. Torchinsky, Tel Aviv, Israel

THE EMBRYO RESPONDING TO TERATOGENIC STRESS: A MODEL FOR DEVELOPING THERAPY SELECTIVELY TRIGGERING APOPTOSIS IN CANCER CELLS

I. Golan, Jerusalem, Israel

NOVEL CD44 VARIANT: POTENTIAL TARGET IN THE THERAPY OF RHEUMATOID ARTHRITIS

16:00 – Coffee

16:30 –18:00

Minisymposium III – Tumor Invasion and Angiogenesis

Chairperson: I. Vlodavsky

L. Medina, Beer-Sheva, Israel

MMP-2 AND MMP–9 ARE DISTINCTLY EXPRESSED AND REGULATED IN OVARIAN CARCINOMA CELL LINE (SKOV-3) TREATED WITH THALIDOMIDE OR PRO-INFLAMMATORY CYTOKINES ANTIBODIES

N. Lahat, Haifa, Israel

Effects of Hypoxia and Reoxygenation on Matrix Metalloproteinase (MMP)-2 Expression in Endothelial Cells

Z. Salah, Jerusalem, Israel

ONCOGENIC TRANSFORMATION INDUCES TUMOR ANGIOGENESIS: A ROLE FOR PAR1 ACTIVATION

O. Goldshmidt, Jerusalem, Israel

CELL SURFACE EXPRESSION AND SECRETION OF HEPARANASE MARKEDLY PROMOTE TUMOR ANGIOGENESIS AND METASTASIS

D. Duś, Wrocław, Poland

ENDOTHELIUM ORGANOSPECIFICITY EVIDENCED BY DIFFERENTIAL ADHESIVE CAPACITIES TOWARDS CANCER CELLS

M.J. Grimshaw, London, UK

Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumour cells

16:30 –18:00

Minisymposium IV - Functions of Cytokines at the Tumor Microenvironment

Chairperson: R. Apte

M.M. Müller, Heidelberg, Germany

G-CSF and GM-CSF contribute to tumor progression in clinical and experimental human tumor systems

E. Neumark, Tel-Aviv, Israel

Pro-Tumorigenic and Anti-Tumorigenic Chemokines, IL-6 and MMPs in Mammary Adenocarcinoma Progression: Co-Regulation by TNFa

L. Mendoza, Leioa, Spain

ENDOSTATIN INHIBITS INTERLEUKIN-18-DEPENDENT METASTASIS BY PREVENTING EFFECTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN TUMOR-ACTIVATED ENDOTHELIUM

B. Filipič, Ljubljana, Slovenia

HUMAN INTERFERON-a AFFECT THE GROWTH PROPERTIES AND MORPHOLOGY OF CELLULAR MICROTUMORS IN VITRO

E. Voronov, Beer-Sheva, Israel

IL-1b as a major activator of angiogenesis

M.C. Dieu-Nosjean, Paris, France

IL-10 INDUCES CCR6 EXPRESSION DURING LANGERHANS CELL DEVELOPMENT WHILE IL-4 AND IFN-g SUPPRESS IT

Friday June 28

08:30 – 10:00

Minisymposium V - The Molecular Basis of Metastasis

Chairperson: D. Zipori

C.A. Klein, München, Germany

MOLECULAR-GENETIC ANALYSIS OF SINGLE DISSEMINATED TUMOR CELLS ISOLATED FROM CARCINOMA PATIENTS

A. Ulmer, Tübingen, Germany

QUANTITATIVE ASSESSMENT AND GENOMIC CHARACTERISATION OF OCCULT TUMOR CELLS IN PERIPHERAL BLOOD OF MELANOMA PATIENTS

S. Hantisteanu, Tel Aviv, Israel

THE EFFECT OF BIOLOGICAL MODIFIERS ON THE EXPRESSION LEVEL OF PYST2 mRNA IN HUMAN MYELOID LEUKEMIA CELL LINES

I. Kindas-Mügge, Vienna, Austria

HEAT SHOCK PROTEIN AND CANCER. OVEREXPRESSION OF THE SMALL HEAT SHOCK PROTEIN hsp27 AFFECTS THE METASTATIC PHENOTYPE OF HUMAN MELANOMA CELLS IN VITRO

A.G. de Nooij-van Dalen, Amsterdam, The Netherlands

MEMBERS OF THE HUMAN LY-6 ANTIGEN FAMILY AS POTENTIAL TARGETS FOR DIAGNOSIS AND THERAPY OF SQUAMOUS CELL CARCINOMA

A. Eden, Cambridge, MA, USA

DNA hypomethylation causes chromosomal instability

S. Mani, Cambridge, MA, USA

Understanding human breast cancer metastasis

08:30 – 10:00

Minisymposium VI - Tumor Immunity and Inflammatory Reactions

Chairperson: E. Klein

E. Klein, Stockholm, Sweden

EPSTEIN BARR VIRUS (EBV) IN HODGKIN´S LYMPHOMA (HL)

R. P. Ciavarra, Norfolk, VA, USA

Impact of the Prostate Tumor Microenvironment on Intra-tumor Dendritic Cells

T. Cramer, San Diego, CA, USA

HIF-1a expression in myeloid cells is an essential regulator of inflammation

N. Rosenzweig, Tel-Aviv, Israel

THE POSSIBLE ROLE OF STROMAL INFLAMMATORY REAcTION IN THE PROMOTION OF PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN) IN RATS

Y. Mahnke, Heidelberg, Germany

A novel model system for the study of anti-tumour T-cell memory

T. Spies, Seattle, WA, USA

Modulation of Anti-Tumor T Cell Responses by NKG2D and its MIC Ligands

10:00 – Coffee

Special Lecture - Introduction by I. Witz

10:30 I.J. Fidler, Houston, TX, USA

THE ROLE OF THE ORGAN MICROENVIRONMENT IN CANCER METASTASIS

Plenary Session VI -Lytic Enzymes in the Tumor Microenvironment

Chairperson: R. Apte

11:10 I. Vlodavsky, Jerusalem, Israel

Properties and function of heparanase in cancer metastasis, angiogenesis and normal development

11:35 R. Fridman, Detroit, MI, USA

REGULATION OF MEMBRANE TYPE-1 MATRIX METALLOPROTEINASES. IMPLICATION FOR PERICELLULAR PROTEOLYSIS IN TUMOR METASTASIS

12:00 R. Bar-Shavit, Jerusalem, Israel

THE INVOLVEMENT OF Protease Activated Receptor1 (PAR1) IN MAMMARY GLAND MORPHOGENESIS AND TUMOR METASTASIS

12:20 – Lunch

Plenary Session VII - Tumor Immunity and Immunotherapy (I)

Chairperson: E. Klein

14:00 C. Sautès-Fridman, Paris, France

Fc GAMMA RECEPTORS AND ST3 IN TUMOR DEVELOPMENT

14:25 M. Kirschfink, Heidelberg, Germany

TUMOR CELL RESISTANCE TO COMPLEMENT-MEDIATED LYSIS: MOLECULAR MECHANISMS AND THERAPEUTIC APPROACHES

14:45 J. Zeromski, Poznań, Poland

IMMUNOBIOLOGY OF CELLS IN THE MICROENVIRONMENT OF MALIGNANT PLEURAL EFFUSIONS

15:10 M.R. Shurin, Pittsburgh, PA, USA

THE DENDRITIC CELL SYSTEM UNDER TUMOR SURVEILLANCE

15:30 M. Micksche, Vienna, Austria

HUMAN TUMOUR-ASSOCIATED MACROPHAGES: ROLE IN DEFENCE AGAINST CANCER CELLS

15:55 – Coffee

Plenary Session VII - Tumor Immunity and Immunotherapy (II)

Chairperson: I. Fidler

16:25 O. Mandelboim, Jerusalem, Israel

RECEPTORS AND LIGANDS INVOLVED IN HUMAN NK CELL CYTOTOXICITY

16:45 D. Zagury, Paris, France

VACCINE TO COMBAT IMMUNOSUPPRESSIVE STROMA-DERIVED FACTOR IN UTERINE CERVIX CANCER

17:05 V. Schirrmacher, Heidelberg, Germany

T CELL MEMORY, ANERGY AND IMMUNOTHERAPY IN BREAST CANCER

17:30 A. Porgador, Beer Sheva, Israel

MICROENVIRONMENT FOR CANCER VACCINATION: ORGAN-SPECIFIC DISTRIBUTION OF VACCINE-INDUCED CD8+ T CELLS

17:50 Y. Keisari, Tel Aviv, Israel

CURE OF TUMOR BEARING MICE AND INDUCTION OF ANTITUMORAL IMMUNE RESPONSE BY A COMBINATION TREATMENT OF CHEMOTHERAPY AND INTRATUMORAL ELECTROSTIMULATION

19:30 - Farewell Evening – Heurigen Streiterhof, Baden

Saturday June 29

Plenary Session VIII - Cytokines in the Tumor Microenvironment

Chairperson: J. Zeromski

08:30 F.R. Balkwill, London, England

CYTOKINES AND CHEMOKINES IN THE TUMOR MICROENVIRONMENT

08:55 F. Vidal-Vanaclocha, Leioa, Spain

CONTRIBUTION OF INTERLEUKIN-18 TO PROMETASTATIC AND PROANGIOGENIC EFFECTS OF INFLAMMATION IN THE LIVER

09:20 W.H. Fridman, Paris, France

MODULATION OF ANTITUMOR IMMUNITY AND VACCINATION BY IL17 AND BACTERIAL PRODUCTS

09:45 R.N. Apte, Beer-Sheva, Israel

DIFFERENTIAL EFFECTS OF IL-1a AND IL-1b IN TUMOR BIOLOGY

10:10 – Coffee

Plenary Session IX - The Regulation of Tumorigenesis and Tumor Progression by Microenvironmental Factors

Chairperson: I. Witz

10:30 N.E Fusenig, Heidelberg, Germany

PERSISTENT STROMA ACTIVATION IS ESSENTIAL FOR TUMOR PROGRESSION AND INVASION

10:55 Y. Kloog, Tel-Aviv, Israel

STRUCTURAL AND BIOCHEMICAL ANALYSIS OF RAS- GALECTIN INTERACTIONS IN CELL TRANSFORMATION

11:15 A. Raz, Detroit, MI, USA

CARBOHYDRATE RECOGNITION DURING METASTASIS

11:40 B. Eliceiri, La Jolla, CA, USA

Role of Integrins and Growth Factor Receptors in Angiogenesis and Tumor Formation

12:05 R.S. Johnson, La Jolla, CA, USA

THE ROLE OF HYPOXIC RESPONSE IN TUMORIGENIC AND NORMAL PHYSIOLOGY

12:30 A. Haimovitz-Friedman, New York, NY, USA

TPA RADIOSENSITIZES PROSTATE CANCER CELLS BY DOWN-REGULATION OF ATM

12:50 – Adjourn