Dr. Dan Frenkel
Ph.D.: Department of Molecular Microbiology and Biotechnology,

Tel Aviv University

2002

Phone:

(Office) +972-3-640-9028
(lab)     +972-3-640-9484

(fax)  972-3-640-9028
E-mail: dfrenkel@post.tau.ac.il
Room#: 424
Member's portrait

Research Interests

Research area: Neuroimmunology, Neurodegenration.

Current Research Topics:  The role  of glia cells during central nervous system inflammation using models of stroke and Alzheimer's disease.

Methods & Techniques: Immunology, Cell biology, Molecular biology, Histology.

.

     Although neurodegenerative diseases are not considered immune mediated, the nature of the immune response is crucial in the application of immunotherapeutic approaches.Resting glia cells are highly sensitive to changes in the tissue microenvironment. Activation is associated with increased production of potentially cytotoxic molecules, including reactive oxygen species (ROS), proteases, and pro-inflammatory cytokines, together with induction of phagocytosis. Their role however, is complex, and different subsets of glia cells can be neuroprotective or neurotoxic. The presence of recruited leukocytes at the site of inflammation is critically dependent upon the coordinated expression of adhesion molecules, ligands and receptors on inflammatory cells and the activated capillary endothelium, respectively. Modulation of neuroinflammation may have applicability both as a preventative therapy and as a treatment in stress and neurodegenerative diseases.

        The research in the lab is focused on understanding glia-neuron interaction to further understand their role in neurological diseases both in culture and in vivo using models of stroke, Alzheimer's disease, and multiple sclerosis.


Students and Lab Members

PhD Student

Veronica Lifshitz              2007-2012

Niva Segev- Amzaleg     2008-2012

Dorit Farfara                     2008-

Dorit Trudler                     2009-

Hilit Levy                            2010-

Tal Iram                             2011-

Sharone Naor                  2012-

M.Sc. students

Dorit Farfara                     2007-2008   "Investigate mechanisms involve in microglia phagocytosis of Abeta"
Hilit Levy                           2007- 2009   "Charcterization of brain lesion in relapsing -remitting mouse model of MS"

Tali Benromano              2008- 2010  " The role of Insulin-Degrading Enzyme in the development of Cerebral Amyloid
                                                                     Angiopathy"

Meital Sooliman              2008- 2011  " Charaterization of a new mouse model for Alzheimer's disease thet has

                                                                     amyloid and tau pathology together with neurodegeneration"

Ronen Weiss                  2009- 2012   "TGF-beta1 affects endothelial cell unteraction with macrophages and T cells

                                                                     leading to the development of cerebrovascular amyloidosis"

Ofir  Fursht                        2011-

Inbal  Buahnik                  2011-

Reserach assistant

Dr. Shani Kanfi

Nofit Bronshtein             2008-2011

 


Courses

1. Research approaches in Neuroimmunology

2. Introduction to inflammatory mechanisms in the CNS

3.


Selected Publications

Peer-review last three years

24.  Hjorth E, Frenkel D, Weiner H, Schultzberg M. “Effects of immunomodulatory substances on phagocytosis of Abeta1-42 by human microglia” International Journal of Alzheimer's Disease, 2010, pii: 798424.

25. Levy H, Assaf Y, Frenkel D. Characterization of brain lesions in a mouse model of progressive multiple sclerosis. Exp Neurol. 2010 226(1):148-58.

26. Farfara D., Trudler D., Amzaleg-Segev  N., Galron R., Stein R., Frenkel D. Gamma-secretase component presenilin mediates microglia beta amyloid clearance. Ann Neurology, 2011, 69(1):170-80. doi: 10.1002/ana.22191.

27. Goldfarb Y, Levi B, Sorski L, Frenkel D, Ben-Eliyahu S “ CpG-C immunotherapeutic efficacy is jeopardized by ongoing exposure to stress: Potential implications for clinical use” Brain Behav Immun. 2011 25(1):67-76

28. Weiss  R. Lifshitz  V, Frenkel  D. TGF-β1 affects endothelial cell interaction with macrophage and Th1 T-cells leading to the development of cerebrovascular amyloidosis”Brain Behav Immun.2011 Jul;25(5):1017-24

29. Frydman-Marom A., Levin A., Farfara D., Benromano T., Scherzer-Attali1 R., Vassar R., Segal D., Gazit E., Frenkel D., and Ovadia M., “Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models” PloS One,  2011.6(1):e16564

30. Lifshitz V., Benromano T., Kfir E.,  Blumenfeld-Katzir T. , Tempel-Brami  C. Assaf   Y., Xia  W., Wyss-Coray  T., Weiner  HL, and Frenkel  D.. “Immunotherapy of cereberovascular amloidosis in a transgenic mouse model” , Neurobiology of aging, 2012  33(2):432.e1-432.e13

31. Galron R., Gruber R. Kirshner M. Ziv  N. Wang  ZO. Shiloh Y. Barzilai A., and Frenkel D.  Glial cells Dysfunction enhanced Neurotoxicity in Nijmegen Breakage Syndrome Animal Model,

JMN 2011 45(2):202-11

32.Raz-Prag D., Galron R., Segev-Amzaleg N., Barzilai A., Shiloh Y., and Frenkel D. ”A role for vascular deficiency  in retinal pathology in a mouse model of ataxia-telangiectasia” , The American Journal of Pathology,Am J Pathol. 2011 ;179(3):1533-41.

 

33. Scherzer-Attali R., Farfara D. , Cooper I., Levin A., Ben-Romano T., Trudler D.,Vientrov M., Shaltiel-Karyo R., Shalev D.E., Segev-Amzaleg N., Gazit E., Segal D. Frenkel D. Naphthoquinone-tyrptophan reduces neurotoxic Abeta*56 levels and improves cognition in Alzheimer's disease animal model, Neurobiol Dis. 2012 ;46(3):663-72.

34. Adler-Abramovich L, Vaks L, Carny O, Trudler D, Magno A, Caflisch A, Frenkel D, Gazit E. Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria.” Nat Chem Biol. 2012.8(8):701-6doi: 10.1038/nchembio.1002.4

 

 

35. Levy-Barazany H. , Frenkel D. “Expression of Scavenger receptor A on antigen presenting cells is important for CD4+T-cells proliferation in EAE mouse model.” Journal of Neuroinflammation 2012, 9:120doi: 10.1186/1742-2094-9-120.

 

36. Meshulam L, Galron R, Kanner S, De Pittà M, Bonifazi P, Goldin M, Frenkel D, Ben-Jacob E, Barzilai .” The role of the neuro-astro-vascular unit in the etiology of ataxia telangiectasia.“FrontPharmacol. 2012;3:157.

 

37. Kirshner M, Galron R, Frenkel D, Mandelbaum G, Shiloh Y, Wang ZQ, BarzilaiA.”Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain.” J MolNeurosci. 2012, 46(3):554-68.

 

38. Avrahami L, Farfara D, Shaham-Kol M, Vassar R, Frenkel D, Eldar-Finkelman H. Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model: IN VIVO AND IN VITRO STUDIES. J Biol Chem. 2013;288(2):1295-306.

 

39. Lifshitz V, Weiss R, Levy H, Frenkel D. (2012) Scavenger Receptor A Deficiency

Accelerates Cerebrovascular Amyloidosis in an Animal Model. 2013 J MolNeurosci2013 50:198-203.

 

40. Lifshitz V, Benromano T, Weiss R, Blanga-Kanfi S, Frenkel D.Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model.  Brain Behav Immun. 2013 30:143-149

 

41. Segev-Amzaleg N, Trudler D, Frenkel D.Preconditioning to mild oxidative stress mediates astroglialneuroprotection in an IL-10-dependent manner. Brain Behav Immun. 2013 30: 176-185

 


CV

      INSTITUTION AND LOCATION

DEGREE

YEAR

FIELD OF STUDY

Technion, Haifa, Israel

B.Sc

1996

Food Engineering and Biotechnology

Tel-Aviv University, Tel-Aviv, Israel

M.Sc

1997

Biotechnology (Alzheimer’s disease)

Tel-Aviv University, Tel-Aviv, Israel

Ph.D

     with distinguish            

2002

Biotechnology (Alzheimer’s disease)

Brigham and Women's hospital and Harvard Medical School, Boston, USA

Research Fellow

2002

Neuroimmunology

(Stroke, Alzheimer's disease, Multiple Sclerosis)

Harvard Medical School, Boston, USA

Instructor

2005

Neuroimmunology

 

Tel Aviv University, Tel Aviv, Israel

Lecturer

2007

Neuroimmunology

 

Tel Aviv University, Tel Aviv, Israel                  Senior Lecturer            2011     Neuroimmunology

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