ד"ר יצחק מיכאלבסקי

סגל אקדמי בכיר בביוכימיה וביולוגיה מולקו
ביוכימיה וביולוגיה מולקו סגל אקדמי בכיר
ניווט מהיר:
טלפון פנימי: 03-6409821
טלפון נוסף: 03-6407971
פקס: 03-6409821

Research Interests

 

Molecular and functional neurobiology of learning and memory

 

1.         Signaling networks evoking gene expression and protein translation responsible for formation of memory

2.         Role of Abelson kinase family in regulation of long-term synaptic plasticity

3.         Role of AKT kinase pathway in regulation of synaptic transmission and long-term synaptic plasticity

 

Molecular pathogenesis of cognitive impairments

 

1.         Molecular mechanism of aging related cognitive impairment in context of stress and depression

2.         Role of tyrosine kinases in amyloid beta impact on synaptic activity 

 

For a more detailed research description

 

Recent Publications

Nesher E, Koman, I, Gross M, Tikhonov T, Bairachnaya M, Gerliz G, Michaelevski I, Yadid G, Pinhasov A Synapsin IIb as a functional marker of submissive behavior Scientific Reports.  2015 May 22;5:10287. doi: 10.1038/srep10287

 

Gross M, Sheinin A, Nesher E, Tikhonov T, Baranes D, Pinhasov,A, Michaelevski I Early onset of cognitive impairment is associated with altered synaptic plasticity and enhanced hippocampal GluA1 expression in a mouse model of depression. Neurobiology of aging. 2015 May;36(5):1938-52. doi: 10.1016/j.neurobiolaging.2015.02.015.

 

Sheinin A, Lavi A, Michaelevski I.  StimDuino: an Arduino-based  electrophysiological stimulus isolator Journal of Neuroscience methods. 2015 Mar 30;243:8-17. doi: 10.1016/j.jneumeth.2015.01.016.

 

Moscovitz O, Tsvetkov P, Hazan N, Michaelevski I, Keisar H, Ben-Nissan G, Shaul Y, Sharon M. A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1. Molecular Cell. 2012 July 13; 47:1-11

 

Michaelevski I, Lotan I. Role of neuronal potassium M-channels in sympathetic regulation of cardiac function. J Physiol. 2011 Jun 1; 589(Pt 11):2659-60

 

Michaelevski I Segal-Ruder Y, Rozenbaum M, Medzihradszky K.F, Shalem O, Coppola G, Horn-Saban S, Ben-Yaakov K, Dagan S.Y, Rishal I, Geshwind D.H, Pilpel Y, Burlingame A.L, & Fainzilber M. Signaling to Transcription Networks in the Neuronal Retrograde Injury response. Science Signaling. 2010 Jun 13; 3(130):ra53

 

Michaelevski I&, Medzihradszky KF, Burlingame,AL & Fainzilber M&: Axonal transport proteomics reveals mobilization translation machinery to the lesion site in injured sciatic nerve. Mol. Cell. Proteomics. 2010 May 9(5):976-87

 

Michaelevski I, Eisenstein M, Sharon M: Gas-phase compaction and unfolding of protein structures. Analytical Chemistry 2010, Nov 15;82(22):9484-91

 

Lvov A, Greitzer D, Chikvashvili D, Tsuk S, Berlin S, Lotan I& and Michaelevski I& Rearrangement in the relative orientation of cytoplasmic domains induced by a membrane anchored protein – mediated Kv channel gating modulation. J Biol Chem 2009, 284(41):28276-91

 

Rishal I, Michaelevski I, Shinder V, Medzihradszky K.F, Burlingame A.L, & Fainzilber M Axoplasm Isolation from Peripheral Nerve. Developmental Neurobiology, 2010 Feb; 70(2):126-33

 

Kirshenbaum N, Michaelevski I, Sharon M. Analyzing Large Protein Complexes by Structural Mass Spectrometry. Journal of Visualized Experiments, 2010; ePublish: http://www.jove.com/index/Details.stp?ID=1954; Review

 

Michaelevski I, Kirshenbaum N, Sharon M. T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis. Journal of Visualized Experiments, 2010; ePublish: http://www.jove.com/index/details.stp?id=1985; Review

 

Feinshreiber L, Chikvashvili D, Michaelevski I, Lotan I. Syntaxin modulates Kv1.1 through dual action on channel surface expression and conductance. Biochemistry. 2009 May 19;48(19):4109-14

 

Tsuk S, Lvov A, Michaelevski I, Chikvashvili D, Lotan I. Formation of the full SNARE complex eliminates interactions of its individual protein components with the Kv2.1 channel. Biochemistry. 2008 Aug 12;47(32):8342-9

 

Lvov A, Chikvashvili D, Michaelevski I, Lotan I. VAMP2 interacts directly with the N terminus of Kv2.1 to enhance channel inactivation. Pflugers Arch. 2008 Sep; 456(6):1121-36

 

Michaelevski I, Korngreen A, Lotan I. Interaction of syntaxin with a single Kv1.1 channel: a possible mechanism for modulating neuronal excitability. Pflugers Arch. 2007 Jun;454(3):477-94

 

Perlson E, Michaelevski I, Kowalsman N, Ben-Yaakov K, Shaked M, Seger R, Eisenstein M, Fainzilber M. Vimentin binding to phosphorylated erk sterically hinders enzymatic dephosphorylation of the kinase.J Mol Biol. 2006 Dec 15;364(5):938-44

 

Wolf-Goldberg T*, Michaelevski I*, Sheu L, Gaisano HY, Chikvashvili D, Lotan I Target soluble N- ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels. Mol Pharmacol. 2006 Sep;70(3):818-28

 

Tsuk S*, Michaelevski I*, Bentley GN, Joho RH, Chikvashvili D, Lotan I Kv2.1 channel activation and inactivation is influenced by physical interactions of both syntaxin 1A and the t-SNARE complex with the C-terminus of the channel. Mol Pharmacol. 2005 Feb; 67(2): 480-8

 

Michaelevski I, Chikvashvili D, Tsuk S, Singer-Lahat D, Kang Y, Linial M, Gaisano HY, Fili O, Lotan I. Direct interaction of target SNAREs with the Kv2.1 channel. Modal regulation of channel activation and inactivation gating. J Biol Chem. 2003 Sep 5;278(36):34320-30

 

Michaelevski I, Chikvashvili D, Tsuk S, Fili O, Lohse MJ, Singer-Lahat D, Lotan I. Modulation of a brain voltage-gated K channel by syntaxin 1A requires the physical interaction of G beta/gamma with the channel. J Biol Chem 2002 Sep 20;277(38):34909-17

 

Fili O*, Michaelevski I*, Bledi Y, Chikvashvili D, Singer-Lahat D, Boshwitz H, Linial M, Lotan I. Direct interaction of a brain voltage-gated K+ channel with syntaxin 1A: functional impact on channel gating. J Neurosci 2001 Mar 15; 21(6):1964-74

 

 

Book Chapters

Michaelevski I, and Fainzilber M. 2007: Proteomic approaches to axon injury –Post-genomic approaches to a post-transcriptional process. IN: Neural Degeneration and Repair – Gene Expression Profiling, Proteomics, Glycomics and Systems Biology. Editor Werner-Mueller H. 2008 Wiley-VCH

 

*- equal contributors
& - corresponding author

 

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