June 28

20:30 – Greetings

21:00 – Opening Lecture – Alexander Levitzki – Hebrew University, Jerusalem
Novel Approaches to Signal Transduction Therapy of Cancer

21:45 – Welcome reception

June 29

9:00 – Isaac Witz – Tel Aviv University, Tel Aviv
The Tumor Microenvironment – Historical Landmarks

9:30-10:30 – Round Table Discussion
– The International Cancer Microenvironment Society – New challenges, tasks and activities

10:30 - Coffee

11:00 – 12:00 - Round Table Discussion
(continuation)

12:00 – Avraham Raz - Wayne State University, Detroit
On the role of galectin-3 in tumor metastasis

12:30 – Yoel Kloog - Tel Aviv University, Tel Aviv
New paradigms in Ras signaling: nanoclusters ,rasosomes and intercellular transfer of Ras

13:00 –Business meeting and Lunch

15:00 – Menashe Bar-Eli - The University of Texas M. D. Anderson Cancer Center, Houston
Gene Regulation in Melanoma Progression

15:30 – Moshe Oren – Weizmann Institute of Science, Rehovot
Involvement of p53 in tumor-stroma cross-talk

16:00 – Coffee

16:30 - Dov Zipori - Weizmann Institute of Science, Rehovot
The tumor initiating cell and its niche

17:00 – Fernando Vidal-Vanaclocha - University of the Basque Country, Leioa, Bizkaia
Gene profile of inflammation-dependent metastatic melanoma

17:30 - Adriana Albini - IRCCS Multimedica, Milan
Targeting chemopreventive drugs to the microenvironment: the angiopreventive activity of natural and synthetic diet derivatives

June 30

9:00-12:30 - Tour in Safed

13:00 –Lunch

15:00 – Eli Keshet - Hebrew University, Jerusalem
VEGF and angiogenic accessory cells

15:30 – Benjamin Sredni – Bar-Ilan University, Ramat Gan
Novel tellurium compounds block angiogenesis by inhibition of cell migration and adhesion

16:00 – Jacques Pouyssegur - University of Nice, Nice
Mechanisms of tumor adaptation to hypoxic and acidic environment

16:30 – Coffee

17:00 – Eli Pikarsky - Hebrew University, Jerusalem
Inflammatory signaling pathways in liver cancer development

17:30 – Jan Zeromski - Medical University, Poznan
Tumor - host struggle: new soldiers and weapons enter the battlefield

July 1

9:00 – Wolf Fridman – Universitι Pierre et Marie Curie, Paris
Shaping an effective immune response in the tumor microenvironment

9:30 – Theresa Whiteside – University of Pittsburgh, Pittsburgh
Human regulatory T cells (Treg) in the tumor microenvironment: phenotype, functions and effects of therapy

10:00 – Ron Apte – Ben-Gurion University of the Negev, Beer-Sheva
The role of the IL-1 molecules in inflammation and immunosurveillance in the malignant process

10:30 - Coffee

11:00 – Michael Shurin - University of Pittsburgh, Pittsburgh
Modulation of the tumor microenvironment by low-dose chemotherapy

11:30 – Yona Keisari - Tel Aviv University, Tel Aviv
Treatment of malignant tumors with a combination of intratumoral 224Ra-loaded wires and chemotherapy: Retardation of primary tumor growth and of lung metastases

12:00 – Eitan Yefenof - Hebrew University, Jerusalem
Thymic micro-environmental encounters and their bearing on the therapy of T cell malignancies

12:30 – Summing up

13:00 – Lunch and Adjourn