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ZOMES
II |
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The COP9
Signalosome, Proteasome and eIF3 at the Crossroads of Signaling
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“ZOMES II”, the 2nd
International Symposium on "The COP9 Signalosome, Proteasome, and
eIF3 at the Crossroads of Signaling” will focus on the structure and
function of the proteasome, the COP9 signalosome, and eIF3, with special attention given to understanding the
connections between these complexes and central signaling pathways. These
three protein complexes are involved independently in the regulation of
transcription, translation and proteolysis. However, these three complexes
share significant structural and genetic similarities, and recent evidence
suggests that there may be direct interactions between the complexes. As
developmental regulation must occur at multiple levels, elucidating the
mechanisms of cross-talk between these and other complexes is of utmost
importance. The study of large protein
complexes -"Zomes" - poses unique issues and
difficulties. The goal of this symposium, as in “ZOMES I”,
is to bring together researchers from diverse fields, in order to initiate
joint efforts for studying the functioning of these complexes. This symposium
will serve as an important venue for discussion of the conservation and
diversity of these complexes. As such, the conference will provide general
overviews of each complex and the pathways they are involved in. One session will be devoted to
understanding the diverse pathways regulated by the COP9 signalosome subunit
CSN5/JAB1. Other regulatory complexes such as the splicesosome, the
SCF-complex, and the ATM-complex, will also be presented. Due to the unfortunate recent developments in Israel, the venue has
been moved to the Turkish Riviera.
Evenings will be free to allow informal gatherings and activities.
There are numerous historic and natural attractions in the area. |
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