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ZOMES
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The COP9
Signalosome, Proteasome and eIF3 at the Crossroads of Signaling
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Keynote Lecture Michael Karin, UCSD, USA, THE IkB kinase (IKK) – A signaling
machine and its role in innate and adaptive immunity Bioinformatics: Comparative Zomes Kay Hofmann, MEMOREC, Germany “Modularity In Protein Recognition And Degradation
Pathways” COP9 signalosome: structure and participation in signaling Thomas Caspari, Germany, “The S. pombe Signalosome
And The DNA Damage Checkpoint Are Both Required For RNR Activation Upon UV
Irradiation In G2” Daniel Chamovitz, Tel Aviv, Israel, ”The COP9 Signalosome
as pleiotropic regulator of Drosophila development” Wolfgang Dubiel, Charité, Germany “COP9
Signalosome-Specifically Phosphorylates p53 That Targets The Tumor Suppressor
To Degradation By The Ubiquitin/26S Proteasome System” Michael Glickman, Technion, Israel “In search of the COP9
signalosome in S. cerevisiae" Ben Zion Levi, Technion, Israel “The Role Of COP9
Signalosome Complex
As An Integrator Of Signals That Modulate ICSBP\IRF-8 Transcriptional
Activity” Michael Naumann, Max Plank, Germany “COP9 Signalosome Directed Regulation
Of NF-kB” Claus Schwechheimer, Tübingen, Germany, “CSN regulates
E3-mediated pathways in Arabidopsis” Ning Wei, Yale, USA “Interaction
Of COP9 Signalosome With SCF Ubiquitin Ligase And Its Functional Implication
In P27kip1 Degradation” The Ubiquitin/Proteasome system: Structure and links to other
signaling pathways Yinon Ben-Neriah, Jerusalem, Israel, Pseudosubstrate-regulation
of pIkBa ubiquitination Aaron Ciechanover, Technion, Israel “Limited Ubiquitin-Mediated
Proteolytic Processing Of The p105 Precursor Of The Transcription Factor
Nf-6b” Ray DeShaies, CalTech, USA “Role Of Reversible Nedd8
Conjugate Formation In Cellular Regulation” Colin Gordon, MRC, Scotland “The Recognition Of
Multi-Ubiquitin In Fission Yeast” Hong-Yong Fu, Taiwan “Mapping Subunit Interactions Within
The Regulatory Particle Of The 26S Proteasome And The COP9 Signalosome:
Comparisons Reveal A Conserved Core Structure” Peter-Michael Kloetzel, Charité, Germany “The Proteasome a-Subunits And Pa28 – Not Only The
Gate” Csaba Koncz, Max Planck, Germany “Snf1-Related Kinases Are
Components Of Proteasome-Associated Scf-Complexes In Arabidopsis” Daniel Kornitzer, Technion, Israel “Substrate Recognition
In SCF-Mediated Ubiquitination” Zhen-Qiang Pan, Mount Sinai, USA “Nedd8 Charged Surface Residues Specifically Mediate The
Activation Of Cdc34 Catalyzed Polyubiquitin Chain Assembly In The Presence Of
Roc1-Cul1” eIF3, translational initiation, and interactions with other
‘zomes’ Albrecht von Arnim, Tennessee, USA “Interactions Between
eIF3 Subunits And The COP9 Signalosome” Chris Norbury, Oxford, UK “AP-1-Dependent Multi-Drug
Resistance Induced By Mpn And Pci Proteins” Nadejda Koloteva-Levine, Tel Aviv, Israel “The Cyclosome Subunit 5 (Apc5) Is
Associated With Ribosomes And Affects Internal Translation Efficiency During
Differentiation” Martin Kupiec Tel Aviv, Israel “A Protein Complex With
Roles In pre-nRNA Splicing And Cell-Cycle Control” Stephane Rety, Lyon, France “Characterization Of The Int-6 Interacting Protein Hspc021
As A Subunit Of The Mammalian Translation Initiation Factor eIF3” Ganes Sen, Case Western, USA, TBA Yossi Shiloh,Tel Aviv, Israel, ATM: Maintaining cellular
homeostasis in the face of dna damage The physiological roles of CSN5/JAB1 Juergen Bernhagen, Stuttgart, Germany “Role Of Jab1/Csn5 In The Signalling Of The Cytokine Macrophage
Migration Inhibitory Factor” Elisabetta Bianchi, San Raffaele, Italy “Integrin Lfa-1
Signalling Synergizes With CSN5 In Regulating AP-1 Activity” Robert M. Gemmill, Colorado, USA “The Hereditary Kidney Cancer Trc8 Gene Functions In
Parallel With Vhl And Affects Drosophila Development” Additional speakers will be chosen from
submitted abstracts. |
Additional support provided by:
