• Electrophilic aromatic fluorinations by elemental fluorine and/or hypofluorites.
  
  
• Reactions of hypofluorite with organometallic derivatives to synthesize
  new organo fluorine compounds.



• Synthesis and Chemistry of XF, XF₃ and XF₅ (X=I,Br).



• Developing the new chemistry of acetyl hypofluorite.



• Activating heterocyclic compounds



• Selective fluorination of biologically important compounds.



• Using fluorine for synthesis of difficult to make fluorine free compounds.



• Fast synthesis of compounds suitable for Positron Emitting Tomography



• HOF-CH₃CN complex,
  the best oxygen transfer agent organic chemistry has to offer.

Last Ten Years

Sharon Dayan, Yifat Bareket and Shlomo Rozen
An Efficient α-Hydroxylation of Carbonyls Using the HOF·CH₃CN Complex
Tetrahedron 1999, 53, 3657.

Andy E. Feiring, E. R. Wonchoba and Shlomo Rozen
Synthesis of Partially Fluorinated Monomers and Polymers for Ion-Exchange Resins
J. Fluorine Chem. 1999, 93, 93.

Joseph Almog, E. Springer, S. Wiesner, A. Frank, O. Khodzhaev, R. Lidor, E. Bahar,
H. Varkony, S. Dayan and Shlomo Rozen
Latent Fingerprint Visualization by 1,2-Indanedione and Related Compounds: Preliminary Results
J. Forensic Sciences, 1999, 114.

Iris Ben David, Dalit Rechavi, Eyal Mishani and Shlomo Rozen
A Novel Synthesis of Trifluoromethyl Ethers via Xanthates Utilizing BrF₃
J. Fluorine Chem. 1999, 97, 75.

Sharon Dayan, Moshe Kol and Shlomo Rozen
Tertiary Amine Oxidation using HOF·CH₃CN: A Novel Synthesis of N-Oxides
Synthesis 1999, 1427.

Shlomo Rozen and Sharon Dayan
At Last, 1,10-Phenanthroline-N,N-Dioxide,
A New Type of Helicene Made by HOF·CH₃CN Complex
Angew. Chem. Int. Ed. Engl. 1999, 38, 3471.

Shlomo Rozen
Reactions of Fluorine in Inert Media
Houben-Weyl Methods of Organic Chemistry,
Vol. E 10a Ed by J. C. Tatlow. Georg Thieme Verlag, 1999, pp. 167.

Ming H. Hung, William B. Farnham, Andy E. Feiring and Shlomo Rozen
Fluoropolymers: Syntheses and Properties. In Functional Fluoromonomers
and Fluoropolymers,
Ed by G. Hougham, T. Davidson and P. Cassidy.
Plenum Publishing Co. 1999, pp. 51.

Shlomo Rozen
HOF·CH₃CN, an Excellent Oxygen Transfer Agent
Pure and Applied Chemistry 1999, 71, 481.

Shlomo Rozen and Ming Hung
Epoxides Containing A Perfluorovinyl Group
USA Patent No 5,914,412 (1999).

Sharon Dayan, Iris Ben-David and Shlomo Rozen
Oxidation of Alkynes by the HOF·CH₃CN Complex
J. Org. Chem. 2000, 65, 8816.

Shlomo Rozen and Iris Ben-David
BrF₃, A Practically New Reagent in Organic Chemistry, Behind a Novel
C-C-N to C-N-C Rearrangement Leading to a New Family of Compounds
J. Org. Chem. 2001, 66, 496 (2001).

Shlomo Rozen, Dalit Rechavi and Aviv Hagooly
Novel Reactions with the Underutilized BrF₃; The Chemistry with Nitriles
J. Fluorine Chem. 2001, 111, 161.

Shlomo Rozen, Aviv Hagooly and Rinat Harduf
Synthesis of α -Fluorocarboxylates From the Corresponding Acids
Using Acetyl Hypofluorite
J. Org. Chem. 2001, 66, 7464.

Aviv Hagooly, Iris Ben-David and Shlomo Rozen
From Alkyl Halides to Alkyltrifluoromethyls Using Bromine Trifluoride
J. Org. Chem. 2002, 67, 8430.

Revital Sasson, Aviv Hagooly and Shlomo Rozen
Novel Method for Incorporating the CHF₂ Group into Organic Molecules Using BrF₃
Org. Lett. 2003, 5, 769.

Shlomo Rozen and Elizabeth Golan
The First General Highly Efficient Method for Making Tetrasubstituted
Epoxides Using HOF·CH₃CN
Eur. J. Org. Chem. 2003, 1915.

Shlomo Rozen and Mira Carmeli
From Azides to Nitro Compounds in a Few Seconds Using HOF·CH₃CN
J. Am. Chem. Soc. 2003, 125, 8118.

Aviv Hagooly, Revital Sasson and Shlomo Rozen
A Novel Method for the Preparation of α, α'-Difluoroesters and Acids Using BrF₃
J. Org. Chem. 2003, 68, 8287.

Elizabeth Golan and Shlomo Rozen
A Fast, High Yield Preparation of Vicinal Dinitro Compounds Using HOF·CH₃CN
J. Org. Chem. 2003, 68, 9170.

Shlomo Rozen
Hypofluorous Acid - Acetonitrile Complex
Invited Contribution for the Electronic Encyclopedia of Reagents for
Organic Synthesis
Ed. by L. A. Paquette, John Wiley & Sons, 2003.

Aviv Hagooly and Shlomo Rozen
The First General Method for α -Trifluoromethylation of Carboxylic Acids
Using BrF₃
Chem. Commun. 2004, 594.

Revital Sasson and Shlomo Rozen
Unique Fluorodecarboxylation using BrF₃ for constructing the CF₃ group
Tetrahedron 2005, 60, 1083.

Mira Carmeli and Shlomo Rozen
The Synthesis of 1,10-N,N'-Phenanthroline Dioxides Using HOF·CH₃CN Complex
J. Org. Chem. 2005, 70, 2131.

Revital Sasson and Shlomo Rozen
From Azides to Nitriles. A Novel Fast Transformation Made Possible by BrF₃
Org. Lett. 2005, 7, 2177.

Aviv Hagooly and Shlomo Rozen
From ketones, aldehydes or alkyl halides to terminal 1,1-difluoroolefins using BrF₃
J. Fluorine Chem. 2005, 126, 1239.

Elizabeth Amir and Shlomo Rozen
The First Synthesis of [All]-S,S-Dioxides Oligothiophenes Using HOF·CH₃CN
Angew. Chem. International Ed. 2005, 44, 7374.

Shlomo Rozen
Elemental Fluorine and HOF·CH₃CN in Service of General Organic Chemistry
Eur. J. Org. Chem. 2005, 2433 - Invited Contribution.

Shlomo Rozen
Attaching the Fluorine Atom to Organic Molecules Using BrF₃ and Other Reagents Directly Derived from F₂.
Accounts of Chemical Research 2005, 38, 803 - Invited Contribution.

Shlomo Rozen
Electrophilic Fluorination with Elemental Fluorine and Reagents Derived from It
in “Advances in Organic Synthesis Vol. 2” Ed. by K. K. Laali and A. U. Rahman; Bentham Science Publishers, Chapter 1, 2006, 3-41 - Invited Contribution.

Shlomo Rozen and Revital Sasson
Bromine Trifluoride Update
Invited Contribution for the Encyclopedia of Reagents for Organic Synthesis Ed. by L. A. Paquette, John Wiley & Sons, 2006, - Invited Contribution.

Mira Carmeli and Shlomo Rozen
A New Very Efficient Deprotection of Azines, Hydrazones and Alike, Presenting Also the Best Route for the R₂C=¹⁶O to R₂C=¹⁸O Transformation
Tetrahedron Lett. 2006, 47, 763.

Or Cohen, Revital Sasson and Shlomo Rozen
A New Method For Making Acyl Fluorides Using BrF₃
J. Fluorine Chem. 2006, 127, 433.

Tal Harel, Elizabeth Amir and Shlomo Rozen
Efficient Synthesis of Episulfones and of SO₂ with Any Variation of Oxygen Isotopes Using HOF·CH₃CN
Org. Lett. 2006, 8, 1213.

Elizabeth Amir and Shlomo Rozen
Easy Access to the Family of Thiazole N-Oxides Using HOF·CH₃CN
Chem. Commun. 2006, 2262.

Mira Carmeli and Shlomo Rozen
Oxidation of Azides by the HOF·CH₃CN.: A Novel Synthesis of Nitro Compounds
J. Org. Chem. 2006, 71, 4585.

Revital Sasson and Shlomo Rozen
Bromofluorination of Olefins Using BrF₃: An Efficient Route for Fluoroalkenes and Fluoroamines
J. Fluorine Chem. 2006, 127, 962.

Mira Carmeli and Shlomo Rozen
A New Efficient Route for the Formation of Quinoxaline N-Oxide and N,N'-Dioxide Using HOF·CH₃CN
J. Org. Chem. 2006, 71, 5761.

Mira Carmeli, Neta Shefer and Shlomo Rozen
From Aldehydes to Nitriles, a General and High Yielding Transformation Using HOF·CH₃CN Complex
Tetrahedron Lett. 2006, 47, 8969.
Tal Harel and Shlomo Rozen
Transforming Natural Amino Acids into α-Alkyl–Substituted Amino Acids with the Help of the HOF·CH₃CN Complex
J. Org. Chem. 2007, 72, 6500.

Neta Shefer, Mira Carmeli and Shlomo Rozen
General, Fast, and High Yield Oxidation of Thiols and Disulfides to Sulfonic and Sulfinic Acids using HOF·CH₃CN
Tetrahedron Lett. 2007, 48, 8178.

Or Cohen and Shlomo Rozen
A general route for the synthesis of β-difluorocarboxylic acids
Tetrahedron 2008, 64, 5362.

Youlia Hagooly, Revital Sasson, Michael. J. Welch and Shlomo Rozen
The Preparation of Alkyl and Aryl Chlorodifluoromethyl Ethers Using BrF₃
Eur. J. Org. Chem. 2008, 2875.

Youlia Hagooly and Shlomo Rozen
Constructing the OCF₂O Moiety Using BrF₃
J. Org. Chem. 2008, 73, 6780.

Youlia Hagooly, Or Cohen and Shlomo Rozen
A General Route for Constructing Difluoromethyl Ethers
Tetrahedron Lett. 2009, 50, 392.

Or Cohen, Youlia Hagooly, and Shlomo Rozen
Replacing the Carbonyl's Oxygen with the Difluoromethyl Group
Tetrahedron 2009, 65, 1361.

Julia Gatenyo and Shlomo Rozen
Direct Addition of Fluorine to Arylacetylenes
J. Fluorine Chem. 2009, 130, 332.

Shlomo Rozen
Editorial
J. Fluorine Chem. 2009, 130, 770.

Neta Shefer, Tal Harel and Shlomo Rozen
Synthesis of Oxygenated Fused Oligothiophene with HOF·CH₃CN
J. Org. Chem. 2009, 74, 6993.

Youlia Hagooly, Julia Gatenyo, Aviv Hagooly and Shlomo Rozen
Toward the Synthesis of the Rare N-(trifluoromethyl)amides and the Novel N-Difluoromethylene-N-(trifluoromethyl)amines [RN(CF₃)CF₂R’] using BrF₃
J. Org. Chem. 2009, 74, 8578-8582.

Maria M. Oliva, Sandra R. Gonzalez, Juan Casado, Juan T. L. Navarrete, J. S. Seixas Melo and Shlomo Rozen
Optical Properties of [all]-S,S-Dioxide Oligothiophenes
Portugaliae Electrochimica Acta 2009, 27, 533.

Or Cohen, Eyal Mishani and Shlomo Rozen
From Carboxylic Acids to the Trifluoromethyl Group using BrF₃
Tetrahedron 2010, 66, XXX.

Tal Harel, Neta Shefer, Youlia Hagooly and Shlomo Rozen
Synthesis of diazafluorene- and diazafluorenone-N,N'-dioxides using HOF·CH₃CN
Tetrahedron 2010, 66, XXX.