email: rozens@post.tau.ac.il
Voice: 972-3-6408378
Fax: 972-3-6409293
Building: Shenkar
Room: 204,309

More information about the Rozen group...  


  • Electrophilic aromatic fluorinations by elemental fluorine and/or hypofluorites.

  • Reactions of hypofluorite with organometallic derivatives to synthesize
    new organo fluorine compounds.


  • Synthesis and Chemistry of XF, XF3 and XF5 (X=I,Br).


  • Developing the new chemistry of acetyl hypofluorite.


  • Activating heterocyclic compounds


  • Selective fluorination of biologically important compounds.


  • Using fluorine for synthesis of difficult to make fluorine free compounds.


  • Fast synthesis of compounds suitable for Positron Emitting Tomography


  • HOF-CH3CN complex,
    the best oxygen transfer agent organic chemistry has to offer.


Academic Experience

  • 1973 Ph. D. Hebrew Uni, Jerusalem, Israel w/Professor E. D. Bergmann

  • 1973-76 Post-doc. Cambridge Mass. USA. w/Professor Sir Derek Barton

  • 1976 Tel-Aviv University, Israel Lecturer

  • 1980 Tel-Aviv University, Israel Senior Lecturer

  • 1985 Tel-Aviv University, Israel Associate Professor

  • 1989 Tel-Aviv University, Israel Full Professor

Awards and Honorary Lectures

  • Teva Founders Award.

  • Incumbent of the Josef Cryss Chair in Organic Chemistry.

  • The American Chemical Society Award for Creative Work in Fluorine Chemistry.

  • The Israel Chemical Society Award for Excellence in Chemistry.

  • Kolthof Award - Administrated by the Technion Israel.

  • Princeton University ("The ACS Lecture of the Month") NJ, USA.

  • University of Lausanne - Special Multi Hours Lecture, Switzerland.

  • Kodak Res. Lab., Weisberger-Williams Special Lecture Series, Rochester, NY, USA.

  • Makhteshim LTD, Y. Sharvit Special Lecture, Beer Sheva, Israel.

  • Novelty in Chemistry - D. H. R. Barton, Special Lecture, The Maldives Islands.

  • Purdue University, H. C. Brown Annual Lecture in Organic Chemistry, IN, USA.

  • Special Lecture - Special guest of Bulgarian Academy of Science, Sofia, Bulgaria.

  • Hebrew University, T. Sheratzky Special Lecture, Jerusalem, Israel.

  • University of Lausanne, Special Multi Hours Course on Fluorine Chemistry We Have Developed, Switzerland

  • Apart from the above more than 150 invited lectures have been presented to academic and industrial chemistry centers around the world.

Consulting for Various Periods

  • Abic Ltd. Israel

  • Eli Lilly Co. USA

  • Sandoz Forschungsinstitut Austria

  • Pierrel S.p.A. Italy

  • Ciba-Geigy Switzerland

  • Israel Bromine Industry Israel

  • Israel Chemical Industries Israel

  • Syntex Bahama

  • Lipiderm Israel

  • Teva Israel

  • Relypsa USA

Special Reviews of Our Work

  • The Editor CHEMTECH, 1982 (Aug), 465.

  • The Editor CHEM. & ENG. NEWS, 1987 (Feb 23), 25.

  • The Editor CHEM. & ENG. NEWS, 1987 (June 29), 22.

  • The Editor CHEM. & ENG. NEWS, 1990 (May 7), 62.

  • The Editor CHEMTECH, 1992 (June), 323.

  • The Editor CHEM. & ENG. NEWS, 1999 (Dec 6), 29.

  • Highlights Section ANGEW. CHEM. INT. ED. 2004, 43, 26.

  • The Editor CHEM. & ENG. NEWS, 2004 (Apr 19), 44.

  • Editorial ISRAEL21C, Inovation Jewish News Center, USA, 2008 (May 13).

  • The Editor CHEM. & ENG. NEWS, 2013 (Apr 15), 21.

  • The Editor CHEM. & ENG. NEWS, 2013, Important news from the 245th ACS meeting in New Orleans.

  • The Editor Chem. Commun.: “Hot Paper” 23 May 2013: The first general route for efficient synthesis of 18O labelled alcohols using the HOF·CH3CN complex

  • According to the book "Organic Synthesis Based on Name Reactions" there are five reactions/reagents called "Rozen reaction/reagent". Few other reactions are dubbed occasionally also as "Rozen Reaction".

Academic Appointments

  • Twelve times DuPont Visiting Scientist at the Central Research Station, Wilmington, Delaware, USA

  • Chairman of the Organic Department - Tel Aviv University

  • Chairman, School of Chemistry - Tel Aviv University

  • Chairman of TEVA Institute of Organic Chem. - Tel Aviv University

  • Member of the Steering Committee for Fluorine Symposia.

  • Guest Editor of the Special Issue on Fluorine Chemistry of the Israel J. Chemistry.

  • Member of the Scientific Advisory Board of the 14th European Symposium on Fluorine Chemistry - Poznan, Poland.

  • Member of the Scientific Advisory Board of the 15th European Symposium on Fluorine Chemistry - Prague, Chech Republic

  • Member of the Advisory Board of the Journal of Fluorine Chemistry.

Cover Pages Representing Rozen's Publications

Touch any of the following pictures to enlarge:

                                     
            Olah's Book                       Angew Chem                     Angew Chem


                                 
              Eur JOC                             Chem Eur J                         Chem Com


Last Ten Years (out of 230 publications)

Revital Sasson, Aviv Hagooly and Shlomo Rozen
Novel Method for Incorporating the CHF2 Group into Organic Molecules Using BrF3
Org. Lett. 2003, 5, 769.

Shlomo Rozen and Elizabeth Golan
The First General Highly Efficient Method for Making Tetrasubstituted
Epoxides Using HOF·CH3CN
Eur. J. Org. Chem. 2003, 1915.

Shlomo Rozen and Mira Carmeli
From Azides to Nitro Compounds in a Few Seconds Using HOF·CH3CN
J. Am. Chem. Soc. 2003, 125, 8118.

Aviv Hagooly, Revital Sasson and Shlomo Rozen
A Novel Method for the Preparation of α, α'-Difluoroesters and Acids Using BrF3
J. Org. Chem. 2003, 68, 8287.

Elizabeth Golan and Shlomo Rozen
A Fast, High Yield Preparation of Vicinal Dinitro Compounds Using HOF·CH3CN
J. Org. Chem. 2003, 68, 9170.

Shlomo Rozen
Hypofluorous Acid - Acetonitrile Complex
Invited Contribution for the Electronic Encyclopedia of Reagents for
Organic Synthesis
Ed. by L. A. Paquette, John Wiley & Sons, 2003.

Aviv Hagooly and Shlomo Rozen
The First General Method for α -Trifluoromethylation of Carboxylic Acids
Using BrF3
Chem. Commun. 2004, 594.

Revital Sasson and Shlomo Rozen
Unique Fluorodecarboxylation using BrF3 for constructing the CF3 group
Tetrahedron 2005, 60, 1083.

Mira Carmeli and Shlomo Rozen
The Synthesis of 1,10-N,N'-Phenanthroline Dioxides Using HOF·CH3CN Complex
J. Org. Chem. 2005, 70, 2131.

Revital Sasson and Shlomo Rozen
From Azides to Nitriles. A Novel Fast Transformation Made Possible by BrF3
Org. Lett. 2005, 7, 2177.

Aviv Hagooly and Shlomo Rozen
From ketones, aldehydes or alkyl halides to terminal 1,1-difluoroolefins using BrF3
J. Fluorine Chem. 2005, 126, 1239.

Elizabeth Amir and Shlomo Rozen
The First Synthesis of [All]-S,S-Dioxides Oligothiophenes Using HOF·CH3CN
Angew. Chem. International Ed. 2005, 44, 7374.

Shlomo Rozen
Elemental Fluorine and HOF·CH3CN in Service of General Organic Chemistry
Eur. J. Org. Chem. 2005, 2433 - Invited Contribution.

Shlomo Rozen
Attaching the Fluorine Atom to Organic Molecules Using BrF3 and Other Reagents Directly Derived from F2.
Accounts of Chemical Research 2005, 38, 803 - Invited Contribution.

Shlomo Rozen
Electrophilic Fluorination with Elemental Fluorine and Reagents Derived from It
in "Advances in Organic Synthesis Vol. 2" Ed. by K. K. Laali and A. U. Rahman; Bentham Science Publishers, Chapter 1, 2006, 3-41 - Invited Contribution.

Shlomo Rozen and Revital Sasson
Bromine Trifluoride Update
Invited Contribution for the Encyclopedia of Reagents for Organic Synthesis Ed. by L. A. Paquette, John Wiley & Sons, 2006, - Invited Contribution.

Mira Carmeli and Shlomo Rozen
A New Very Efficient Deprotection of Azines, Hydrazones and Alike, Presenting Also the Best Route for the R2C=16O to R2C=18O Transformation
Tetrahedron Lett. 2006, 47, 763.

Or Cohen, Revital Sasson and Shlomo Rozen
A New Method For Making Acyl Fluorides Using BrF3
J. Fluorine Chem. 2006, 127, 433.

Tal Harel, Elizabeth Amir and Shlomo Rozen
Efficient Synthesis of Episulfones and of SO2 with Any Variation of Oxygen Isotopes Using HOF·CH3CN
Org. Lett. 2006, 8, 1213.

Elizabeth Amir and Shlomo Rozen
Easy Access to the Family of Thiazole N-Oxides Using HOF·CH3CN
Chem. Commun. 2006, 2262.

Mira Carmeli and Shlomo Rozen
Oxidation of Azides by the HOF·CH3CN.: A Novel Synthesis of Nitro Compounds
J. Org. Chem. 2006, 71, 4585.

Revital Sasson and Shlomo Rozen
Bromofluorination of Olefins Using BrF3: An Efficient Route for Fluoroalkenes and Fluoroamines
J. Fluorine Chem. 2006, 127, 962.

Mira Carmeli and Shlomo Rozen
A New Efficient Route for the Formation of Quinoxaline N-Oxide and N,N'-Dioxide Using HOF·CH3CN
J. Org. Chem. 2006, 71, 5761.

Mira Carmeli, Neta Shefer and Shlomo Rozen
From Aldehydes to Nitriles, a General and High Yielding Transformation Using HOF·CH3CN Complex
Tetrahedron Lett. 2006, 47, 8969.

Tal Harel and Shlomo Rozen
Transforming Natural Amino Acids into α-Alkyl-Substituted Amino Acids with the Help of the HOF·CH3CN Complex
J. Org. Chem. 2007, 72, 6500.

Neta Shefer, Mira Carmeli and Shlomo Rozen
General, Fast, and High Yield Oxidation of Thiols and Disulfides to Sulfonic and Sulfinic Acids using HOF·CH3CN
Tetrahedron Lett. 2007, 48, 8178.

Or Cohen and Shlomo Rozen
A general route for the synthesis of β-difluorocarboxylic acids
Tetrahedron 2008, 64, 5362.

Youlia Hagooly, Revital Sasson, Michael. J. Welch and Shlomo Rozen
The Preparation of Alkyl and Aryl Chlorodifluoromethyl Ethers Using BrF3
Eur. J. Org. Chem. 2008, 2875.

Youlia Hagooly and Shlomo Rozen
Constructing the OCF2O Moiety Using BrF3
J. Org. Chem. 2008, 73, 6780.

Youlia Hagooly, Or Cohen and Shlomo Rozen
A General Route for Constructing Difluoromethyl Ethers
Tetrahedron Lett. 2009, 50, 392.

Or Cohen, Youlia Hagooly, and Shlomo Rozen
Replacing the Carbonyl's Oxygen with the Difluoromethyl Group
Tetrahedron 2009, 65, 1361.

Julia Gatenyo and Shlomo Rozen
Direct Addition of Fluorine to Arylacetylenes
J. Fluorine Chem. 2009, 130, 332.

Shlomo Rozen
Editorial
J. Fluorine Chem. 2009, 130, 770.

Neta Shefer, Tal Harel and Shlomo Rozen
Synthesis of Oxygenated Fused Oligothiophene with HOF·CH3CN
J. Org. Chem. 2009, 74, 6993.

Youlia Hagooly, Julia Gatenyo, Aviv Hagooly and Shlomo Rozen
Toward the Synthesis of the Rare N-(trifluoromethyl)amides and the Novel N-Difluoromethylene-N-(trifluoromethyl)amines [RN(CF3)CF2R'] using BrF3
J. Org. Chem. 2009, 74, 8578.

Maria M. Oliva, Sandra R. Gonzalez, Juan Casado, Juan T. L. Navarrete, J. S. Seixas Melo and Shlomo Rozen
Optical Properties of [all]-S,S-Dioxide Oligothiophenes
Portugaliae Electrochimica Acta 2009, 27, 533.

Or Cohen, Eyal Mishani and Shlomo Rozen
From Carboxylic Acids to the Trifluoromethyl Group using BrF3
Tetrahedron 2010, 66, 3579.

Tal Harel, Neta Shefer, Youlia Hagooly and Shlomo Rozen
Synthesis of diazafluorene- and diazafluorenone-N,N'-dioxides using HOF·CH3CN
Tetrahedron 2010, 66, 3297.

Tal Harel and Shlomo Rozen
The Tetrazole 3-N-Oxide Synthesis.
J. Org. Chem. 2010, 75, 3141.

M. Oliva, C. J. Casado, N. Lopez, J. Teodomiro, S. Patchkovskii, T. Goodson, M. Harpham, S. J. Melo, E. Amir and S. Rozen
Do [all]-S,S'-Dioxide Oligothiophenes Show Electronic and Optical Properties of Oligoenes and/or of Oligothiophenes?
J. Am. Chem. Soc. 2010, 132, 6231.

Neta Shefer and Shlomo Rozen
The Oxygenation of Thieno[2,3-b]thiophenes
J. Org. Chem. 2010, 75, 4623.

Youlia Hagooly, Michael J. Welch and Shlomo Rozen
Synthesis of Difluoroaryldioxoles Using BrF3
Org. Bio. Chem. 2011, 9, 902.

Neta Shefer and Shlomo Rozen
Synthesis of Thienopyrrols using HOF·CH3CN
J. Org. Chem. 2011, 76, 4611.

Shay Potash and Shlomo Rozen
[All]-S,S-Oxygenated Star Oligothiophenes
J. Org. Chem. 2011, 76, 7245.

Julia Gatenyo, Youlia Hagooly, Inna Vints and Shlomo Rozen
Activation of a CH bond in polypyridine systems by acetyl hypofluorite made from F2
Org. Bio. Chem. 2012, 10, 1856.

Youlia Hagooly and Shlomo Rozen
Pyridine-BrF3, the Missing Link for Clean Fluorinations of Aromatic Derivatives
Org. Lett. 2012, 14, 1114.

A. Amirav, A. Gordin, Y. Hagooly, S. Rozen, B. Belgorodsky, B. Seemann, H. Marom, M.Gozin and A. B. Fialkov
Measurement and Optimization of Organic Chemical Reaction Yields by GC-MS with Supersonic Molecular Beams
Tetrahedron 2012, 68, 5793.

Julia Gatenyo, Kevin Johnson, Anuruddha Rajapakse, Kent S. Gates, and Shlomo Rozen
Transferring oxygen isotopes to 1,2,4-benzotriazine 1-oxides forming the corresponding 1,4-dioxides by using the HOF·CH3CN complex
Tetrahedron 2012, 68, 8942.

Inna Vints, Julia Gatenyo and Shlomo Rozen
Mono and difluorination of centers alpha to sulfonates and phosphonates using AcOF
J. Fluorine Chem. 2013, 146, 66.

Shay Potash and Shlomo Rozen
New Conjugated Oligothiophenes Containing the Unique Arrangement of Internal Adjacent [All]-S,S-Oxygenated Thiophene Fragments
Chem. A European J. 2013, 19, 5289.

Julia Gatenyo, Inna Vints and Shlomo Rozen
The First General Route for Efficient Synthesis of [18]O Labelled Alcohols Using the HOF·CH3CN complex
Chem. Commun. 2013, 49, 7379.

Shay Potash and Shlomo Rozen
A General and Efficient Method for Converting Selenides to Selenones by Using HOF·CH3CN
European J. Org. Chem. 2013, 5574.

Shlomo Rozen
The Versatile Chemistry of Acetyl Hypofluorite - The First Hypofluorite not Bonded to Polyhaloalkyl group Efficient Preparations of Fluorine Compounds
Ed. by H. W. Roesky. John Wiley & Sons, 2013, 139.

Shlomo Rozen
Direct Fluorination of Organic Compounds with Elemental Fluorine Efficient Preparations of Fluorine Compounds
Ed. by H. W. Roesky. John Wiley & Sons, 2013, 146.

Shlomo Rozen
The Surprising Chemistry of Bromine Trifluoride Efficient Preparations of Fluorine Compounds
Ed. by H. W. Roesky. John Wiley & Sons, 2013, 154.

Inna Vints, Julia Gatenyo and Shlomo Rozen
Fluorination of aryl boronic acids using acetyl hypofluorite made directly from diluted fluorine
Submitted