Yoram Cohen's Group
Supramolecular Chemistry and MRI/MRS of the Central Nervous System

School of Chemistry, Tel-Aviv University

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Articles
120. N. Shemesh, Y. Cohen, Microscopic and Compartment Shape Anisotropies in Grey and White Matter Revealed by Angular Bipolar Double-PFG MR. Magn. Reson. Med., 65, 1216-1227 (2011)
119. L. Avram, Y. Cohen, J. Rebek Jr., Recent Advances in Hydrogen-Bonded Hexameric Encapsulation Complexes. Chem. Comm. 47, 5368-5375 (2011)
118. N. Shemesh, Y. Cohen, Probing Microscopic Architecture of Opaque Heterogeneous Systems Using Double-PFG NMR, J. Am. Chem. Soc. 133, 6028-6035 (2011)
117. M. E. Komlosh, E. Ozarslan, M. Lizak, F. Horkay, V. Scharm, N. Shemesh, Y. Cohen, P. J. Basser
Pore Diameter Mapping Using Double Pulsed Field Gradient MRI and its Validation Using a Novel Glass Capillary Phantom. J. Magn. Reson., 208, 128-135 (2011)
116. E. Ozarslan, N. Shemesh, C. G. Koay, Y. Cohen, P. J. Basser, NMR Characterization of General Compartment Size Distributions. New J. Physics, 13, 015010(1-17) 2011
115. S. Slovak, Y. Cohen, In-Out Interactions of Different Guests with the Hexameric Capsule of Resorcin[4]arene. Supramolecular Chem., 22, 803-807 2010.
114. S. Slovak, T. Evan-Salem, Y. Cohen, Self-Assembly of Hexameric Aggregate of a Lipophilic Calix[4]]Pyrrole- Resorcinarene Hybrid in Solution: A Diffusion NMR Study. Org. Letters, 12, 4864-4867 (2010).
113. N. Shemesh, E. Ozarslan, T. Adiri, P. J. Basser, Y. Cohen, Non-invasive Bipolar Double-PFG NMR Reveals Signatures for Pore Size and Shape in Polydisperse, Randomly Oriented Inhomogeneous Porous Media. J. Chem. Phys. 133, 044705(1-9) (2010).
112. N. Shemesh, E. Ozarslan, M.E. Komlosh, P. J. Basser, Y. Cohen, From Single-PFG to Double-PFG MR: Gleaning New Micro-structural Information and Developing New forms of Contrast in MRI. NMR in Biomed. 23, 757-780 (2010).
111. N. Shemesh, E. Ozarslan, P. J. Basser, Y. Cohen, Detecting diffusion-Diffraction Patterns in Size Distribution Phantoms Using Double-Pulsed Field Gradient (d-FPG) NMR: Theory and Experiments.
J. Chem. Phys. 132, 034703(1-12) (2010).
110. S. Slovak, L. Avram, Y. Cohen, "Encapsulated or not Encapsulated": Mapping Alcohol Sites in Hexameric Capsules of Resorcin[4]arenes in Solution by Diffusion NMR. Angew Chem. Int. Ed. 49, 428-431 (2010).
109. A. Bar-Shir, N. Shemesh, R. Nossin-Manor, Y. Cohen, Long Therapeutic Window in Sphenopalatine Ganglion Stimulated Ischemic Rats: An MRI and MRS Study. J. Magn. Reson. Imaging, 31, 1355-1363 (2010).
108. N. Shemesh, O. Sadan, E. Melamed, D. Offen, Y. Cohen, Longitudinal MRI and MRS Characterization of the Quinolinic Acid Lesion Rat Model of Huntington's Disease: Low Apparent Diffusion Coefficients After 49 Days and Spontaneous Recovery of N-Acetyl Aspartate Levels. NMR in Biomed. 23, 196-206 (2010).
107. N. Shemesh, E. Ozarslan, A. Bar-Shir, P. J. Basser, Y. Cohen, Observation of Restricted Diffusion in the Presence of a Freely Diffusing Compartment: Single- and Double-PFG MR experiments. J. Magn. Reson. 200, 214-225 (2009).
106. A. Bar-Shir, I. D. Duncan, Y. Cohen, QSI and DTI of Excised Brains of Myelin-Deficient Rat Neuroimage, 48, 109-116 (2009).
105. O. Sadan, M.Bahat-Stromza, Y. Barhum, Y. S. Levy, A. Pisnevsky, H. Peretz, A. Bar Ilan, S. Bulvik, N. Shemesh, D. Krepel, Y. Cohen, E. Melamed, D. Offen, Protective effects of neurotrophic factors secreting cells in a 6OHDA rat model of Parkinson disease. Stem Cells and Development, 18, 1179-1190 (2009).
104. O. Sadan, N. Shemesh, Y. Cohen, E. Melamed, D. Offen, Adult Neurotrofic Factors-Secreting Stem Cells: A Potential Novel Therapy for Neurodegenerative Diseases. Israel Med. Assoc. J. 11, 201-204 (2009).
103. E. Wirtheim, L. Avram and Cohen Y, Thio-Ether-Footed Resorcin[4]arenes: Self-Assembly in Solutions and Interaction with Gold Nanoparticles as Viewed by Diffusion NMR. Tetrahedron, 65, 7268-7276 (2009).
102. N. Shemesh, E. Özarslan, P. J. Basser and Y. Cohen, Measuring Small Compartmental Dimensions with Low-q Angular Double-PGSE NMR: The effect of Experimental Parameters on Signal Decay.
J. Magn. Reson. 189, 15-23 (2009).
101. N. Shemesh, Y. Cohen, The Effect of Experimental Parameters on the Signal Decay in Double-PGSE Experiments: Negative Diffractions and Enhancement of Structural Information. J. Magn. Reson. 195, 153–161 (2008).
100. G. Gattuso, A. Notti, A. Pappalardo, M. F. Parisi, I. Pisagatti, S. Pappalardo, D. Grozzo, A. Messina, Y.Cohen, S. Slovak, Self-Assembly of Modular Homoditopic Bis-calix[5]arene and Long Chained a,w-Alkanediyldiammonium Components. J. Org. Chem. 73, 7280-7289 (2008).
99. A. Bar-Shir, L. Avram, E. Özarslan, P. J. Basser and Y. Cohen,
The Effect of Diffusion time and Pulse Gradient Duration Ratio on the Diffraction Patterns and the Structural Information Extracted from the q-Space Diffusion MR: Experiments and Simulations.
J. Magn. Reson. 194, 230-236 (2008).
98. O. Sadan, N. Shemesh, M. Bahat-Storma, E. Melamed, Y. Cohen, D. Offen,
Migration of Neurotrofic Factors-Secreting Mesenchymal Stem Cells Towards a Quinolinic Acid Lesion as Viewed by MRI. Stem Cells. 26, 2542-2551 (2008).
97. L. Avram, E. Özarslan, Y. Assaf, A. Bar-Shir, Y. Cohen, P. J. Basser, Three-Dimensional Water Diffusion within Impermeable Cylindrical Tubes: Theory vs. MR Experiments. NMR in Biomedicine, 21, 888-898 (2008).
96. A. Bar-Shir, Y. Cohen, Crossing Fibers, Diffractions and Non-Homogeneous Magnetic Field: Correction of Artifacts by Bipolar Gradient Pulses. Magn Reson. Imaging, 26, 801-808 (2008).
95. L. Avram, Y. Cohen, Diffusion NMR of the Self-Assembly of Resorcin[4]arene in the Presence of Small Alkyl ammonium Guests in Solution. Org. Letters, 10, 1505-1508 (2008).
94. Y. Cohen, T. Evan-Salem, L. Avram, Hydrogen-bonded Hexameric Capsules of Resorcin[4]arene, Pyrogallol[4]arene and Octahydroxypyridine[4]arene are Abundant Structures in Organic Solvents: A View from Diffusion NMR. Supramolecular Chem. 20, 71-79 (2008).
93. A. Bar-Shir, Y. Cohen, The Effect of the Rotational angle on MR Diffusion Parameters: Is the Minimal Diffusivity a Better Parameter for Determining Fiber Orientation. J. Magn. Reson. 190, 33-42 (2008).
92. I. E. Biton, I. D. Duncan, Y. Cohen, Myelin, Diffusion Time and Apparent Anisotropy in the CNS: Time Dependent q-Space Diffusion Spectroscopy and Imaging of Excised Myelin Deficient Rat Spinal. Cords. Magn. Reson. Med., 58, 993-1000 (2007).
91. T. Evan-Salem, Y. Cohen, Octahydroxypyridine[4]arene Self-Assembles Spontaneously into Hexameric Capsules and Dimeric Aggregates in Chloroform Solution. Chem. Eur. J., 13, 7659-7663 (2007).
90. M. Parisi, S. Pappalardo, V. Villari, S. Slovak, Y.Cohen, G. Gattuso, A. Notti, A. Pappalardo, I.Pisagatti. Counterion Dependent Proton-Driven Self-Assembly of Linear Supramolecular Oligomers Based on Amino-Calix[5]arene Building Blocks. Chem. Eur. J., 13, 8164-8173 (2007).
89. I. Zigelboim. D. Offen, E. Melamed, H. Panet, M. Rehavi, Y. Cohen. Preparation and Binding Affinity of Target-Specific MRI Contrast Agents: En Route for Molecular Imaging of Specific Receptors with MRI. J. Incl. Phenom. Macrocycl. Chem., 59, 323-329 (2007).
88. R. Nossin-Manor, R. Duvdevani, Y. Cohen. Spatial and Temporal Damage Evaluation Following Hemi-Crish Injury in Rat Spinal Cord Obtained by High b Value q-Space Diffusion MRI. J. Neurotrauma, 24, 481-491 (2007).
87. O. Mayzel-Oreg, Y. Assaf, A. Gigi, D. Ben-Bashat, R. Verchovsky, M. Mordohovitch, M. Graif, T. Hendler, A. D. Korczyn, Y. Cohen. q-Space Diffusion Imaging of Dementia: Application to Vascular Dementia and Alzheimer Disease. J. Neurol. Sciences, 257, 105-113 (2007).
86. A. Bar-Shir, Y. Cohen, High b-Value q-Space Diffusion MRS of Nerves: Structural Information and Comparison with Histology. NMR in Biomedicine, 21, 165-174 (2008).
85. T. Evan-Salem, L. Frish, F. W. B. van Leeuwen, D. N. Reinhoudt, W. Verboom, M. S. Kaucher, J. T. Davis, Y. Cohen. Self-Assembled Ionophores from Isoguanosine: Diffusion NMR Clarifies Cation's and Anion's Influence on Supramolecular Structure. Chem. Eur. J., 13, 1969-1977 (2007).
84. T. Evan-Salem, I. Baruch, L. Avram, Y. Cohen, L C. Palmer, J. Rebek Jr. Resorcinarenes are Hexameric Capsules in Solution. Proc. Natl. Acad. Sci. USA, 103, 12296-12300 (2006).
83. F. Gulion, R. Lauceri, L. Frish, T. Evan-Salem, Y. Cohen, R. De Zorzi, S. Geremia, L. Di Costanzo, L. Randaccio, D. Sciotto, R. Purrello, Non-Covalent Synthesis in Aqueous Solution and Spectroscopic Characterization of Multi-Porphyrins Complexes. Chem. Eur. J., 12, 2722-2729 (2006).
82. L. Avram, Y. Cohen, Molecules at Close Range: Encapsulated Solvent Molecules in Pyrogallol[4]arene Hexameric Capsules. Org. Letters, 8, 219-222 (2006).
81. I. E. Biton, I. D. Duncan, Cohen Y, High b-Value q-Space Diffusion MRI in Myelin-Deficient Rat Spinal Cords. Magn. Reson. Imaging, 24, 161-166 (2006).
80. S. Rochkind, A. Shahar, D. Fliss, D. El-Ani, L. Astachov, T. Hayon, M. Alon, R. Zamostiano, O. Ayalon, I. E. Biton, Y. Cohen, R. Halperin, D. Schneider, A. Oron, Z. Nevo, Development of Tissue-Engineered Composite Implant for Treating Traumatic Paraplegia in Rats. Eur.  Spine J., 15, 234-245 (2006).
79. E. Bukhaltsev, L. Frish, Y. Cohen and A. Vigalok, Single-Site Catalysis by Bimatallic Zinc Calixarene Inclusion Complexes. Org. Letters, 7, 5123-5126 (2005).
78. Y. Assaf, J. Chapman, T. Hendler, D. Ben-Bashat, Y. Segev, A. D. Korczyn, M. Graif, Y. Cohen, White Matter Changes in Multiple Sclerosis: Correlation of q-Space Diffusion MRI and 1H MRS.      Magn. Reson. Imaging, 23, 703-710 (2005).
77. I. E. Biton, A. Mayk, D. Kidron, Y. Assaf, Y. Cohen, Improved Detectability of Experimental Allergic Encephalomyelitis in Excised Swine Spinal Cord by High b-Value q-Space DWI. Exp. Neurology, 195, 437-446 (2005).
76. D. Ben Bashat, L. Ben Sira, M. Graif, P. Pianka, T. Hendler, Y. Cohen, Y. Assaf, Normal White Matter Development from Infancy to Adulthood: Comparing Diffusion Tensor and High B value Diffusion Weighted MR images. J. Magn. Reson. Imaging, 21, 503-511 (2005).
75. L. Avram and Y. Cohen, Diffusion Measurements for Molecular Capsules: Pulse Sequence Effect on Water Signal Decay. J. Am. Chem. Soc.,127, 5714-5719 (2005).
74. E. Meshorer, I. E. Biton, Y. Ben-Shaul, Y. Assaf, H. Soreq, Y. Cohen, Chronic Cholinergic Imbalances Promote Brain Diffusion and Transport Abnormalities. FASEB Journal, 19, 910-922 (2005)
73. R. Nossin-Manor, R. Duvdevani, Y. Cohen, The Effect of Experimental Parameters on High b-Value q-Space MR Images of Rat Spinal Cord. Magn. Reson. Med., 54, 96-104 (2005).
72. O. Segev, I. Columbus, Y. Ashani, Y. Cohen, Probing the Molecular Interaction of Chymotrypsin with Organophosphorus Compounds by 31P Diffusion NMR in Aqueous Solutions.
J. Org. Chem., 70, 309-314 (2005).
71. Y. Cohen, L. Avram, L. Frish, Diffusion NMR Spectroscopy in Supramolecular and Combinatorial Chemistry: An Old Parameter New Insights. Angew. Chem. Int. Ed., 43, 520-554 (2005).
70. L. Avram, Y. Cohen, Self-Recognition, Structure, Stability and Guest Affinity of Pyrogallol[4]arene and Resorcin[4]arene Capsules in Solution. J. Am. Chem. Soc.,126, 11556-11563 (2004). See also  C&N News January 3, 2005, 30-31.
69. S. D. Bergman, D. Reshef, L. Frish, Y. Cohen, I. Goldberg, From Eilatin to Isoeilatin: A Skeltal Rearangement Strongly Influences p-Stacking of Ru(II) Complex. Inorganic Chem.,43, 3792-3794 (2004).
68. L. Frish, N. Friedman, M. Sheves, Y. Cohen, The Interaction of Water Molecules with Purple Membrane in Suspension Using 2H Double Quantum Filter and 1H and 2H Diffusion NMR. Biopolymers,75, 46-59 (2004).
67. L. Avram, Y. Assaf, Y. Cohen, The Effect of Rotational Angle, the Pulse Gradient Duration and the Diffusion Time on the Diffraction Patterns and the Micro Structural Information Obtained from q-Space Diffusion NMR. J. Magn. Reson., 169, 30-38 (2004).
66. O. Mayzel-Oreg, T. Omae, M. Kazemi, F. Li, M. Fischer, Y. Cohen, C. H. Sotak, Microsphere-induced Embolic Stroke: A MRI Study. Magn. Reson. Med.,51, 1232-1238 (2004).
65. M. Ben Moshe, S. Megdassi, Y. Cohen, L. Avram, Structure of Microemulsion with Gemini Surfactant Studied by Solvatochromic Probe and Diffusion NMR. J. Colloid Interface Sci., 276, 221-226 (2004).
64. E. Biton, A. Mayk, Y. Assaf, Y. Cohen, Structural Changes in Glutamate Cell Swelling Followed by Multiparametric q-Space Diffusion MR of Excised Rat Spinal Cord. Magn. Reson. Imaging, 22, 661-672 (2004).
63. L. Avram and Y. Cohen, Discrimination of Guests Encapsulation in Large Hexameric Molecular Capsules in Solution: Pyrogallolarene Versus Resorcinarene Capsules. J. Am. Chem. Soc., 125, 16180-16181 (2003).
62. L. Avram, Y. Cohen, Hexameric Capsule of Lipoohilic Pyrogallolarene and Resorcinarene in Solutions as Probed by Diffusion NMR: One Hydroxyl Group Makes the Difference. Org. Lett., 5, 3329-3332 (2003).
61. Frish, M. O. Vysotsky, V. Bohmer, and Y. Cohen, Compensation of Steric Demand by Cation-p Interactions, Cobaltocenium Cations as Guest in Tetraurea Calix[4]arene Dimers. Org&Biomolecular Chem., 1, 2011-2014 (2003). (Journal Cover page).
60. L. Avram and Y. Cohen, Effect of Cationic Guest on the Characteristics of the Molecular Capsule of Resorcinarene: A Diffusion NMR Study. Org. Lett., 5, 1099-1102 (2003).
59. Y. Assaf, A. Mayk, S. Eliash, Z. Speiser, and Y. Cohen, Hypertension and Neuronal Degeneration in Excised Rat Spinal Cord Studied by High-b-Value q-Space Diffusion Magnetic Resonance Imaging. Exp. Neurology, 184, 726-736 (2003).
58. L. Avram, and Y. Cohen, The Role of Water Molecules in a Resocinarene Capsule as Probed by NMR Diffusion Measurements. Org. Lett., 4, 4365-4368 (2002).
57. L. Avram, and Y. Cohen, Spontaneous Formation of Hexameric Resorcinarene Capsule in Chloroform Solution as Detected by Diffusion NMR. J. Am. Chem. Soc.,124, 15148-15149 (2002).
56. Y. Assaf, O. Mayzel-Oreg, A. Gigi, D. Ben-Bashat, M. Mordohovitch, R. Verchovsky, I. Reider-Grosswasser, Y. Hendler, Y. Cohen, A. D. Korczyn, High b Value q-Space-Analyzed Diffusion MRI in Vascular Dementia. J. Neurol. Sciences, 203-204, 235-239 (2002).
55. Y. Cohen, Y. Assaf, High b Value q-Space Analyzed Diffusion-Weighted MRI: From in Vitro Spinal Cord to Multiple Sclerosis. NMR in Biomed.,15, 516-542 (2002).
54. L. Avram, and Y. Cohen, Complexation in Pseudorataxanes Based on a-Cyclodextrin and Different a,w-Diaminoalkanes by NMR Diffusion Measurements. J. Org. Chem., 67, 2639-2644 (2002).
53. R. Nossin-Monar, R. Duvdevani, and Y. Cohen, q-Space High b Value Diffusion MRI of Hemi-Crush in Rat Spinal Cord: Evidence for Spontaneous Regeneration. Magn. Reson. Imaging, 20, 231-241 (2002).
52. Y. Assaf, M. Kafri, H. Shinar, J. Chapman, A. D. Korczyn, G. Navon, and Y. Cohen, Changes in Axonal Morphology in Experimental Autoimmune Neuritis as Studied by q-Space 1H and 2H DQF Diffusion Magnetic Resonance Spectroscopy. Magn. Reson. Med.,48, 71-81 (2002).
51. Y. Assaf, D. Ben-Bashat, J. Chapman, S. Peled, I. E. Biton, M. Kafri, Y. Segev, T. Hendler, A. D. Korczyn, M. Graif, and Y. Cohen, High b-Value q-Space Analyzed Diffusion-Weighted MRI: Application to Multiple Sclerosis. Magn. Reson. Med., 47, 115-126 (2002).
50. L. Frish, M. O. Vysotsky, S. E. Matthews, V. Bohmer, and Y. Cohen, Tropylium Cation Capsule of Hydrogen-Bonded Tetraurea Calix[4]arene Dimers J. Chem. Soc. Perkin 2, 88-93 (2002).
49. L. Beni-Adani, I. Gozes, Y. Cohen, Y. Assaf, R. A. Steingart, D. E. Brenneman, O. Eizenberg, V. Tremblover, and E. Shohami, A Peptide Derived from Activity-Dependent Neuroprotective Protein (ADNP) Ameliorates Injury Response in Closed Head Injury in Mice. J. Pharm. & Exp. Therapeutics, 296, 57-63 (2001).
48. P. Timmerman, J.-L. Weidmann, K. A. Jolliffe, L. J. Prins, D. N. Reinhoudt, S. Shinkai, L. Frish, and Y. Cohen, NMR Diffusion Spectroscopy for the Characterization of Multicomponent Hydrogen- Bonded Assemblies in Solution. J. Chem. Soc. Perkin 2, 2077-2089 (2000).
47. Y. Assaf, A. Mayk, and Y. Cohen, Displacement MRI of the Spinal Cord Using q-Space Diffusion-Weighted MRI. Magn. Reson. Med.,44, 713-722 (2000).
46. L. Frish, F. Sansone, A. Casnati, R. Ungaro and Y. Cohen, Complexation of the Peptidocalix[4]arene Vancomycin Mimics with Alanine Containing Guests by NMR Diffusion Measurements. J. Org. Chem., 65, 5026-5030 (2000).
45. M. Greenwald, D. Wessely, E. Katz, I. Willner, and Y. Cohen, From Homeleptic to Heteroleptic Double-Stranded Copper (I) Helicates: The Importance of Self-Recognition in Self-assembly Processes. J. Org. Chem., 65, 1050-1058 (2000).
44. Y. Assaf, and Y. Cohen, Assignment of the Water Slow-Diffusing Component in the Central Nervous System Using q-Space Diffusion MRS: Implications for Fiber Tract Imaging. Magn. Reson. Med., 43, 191-199 (2000).
43. M. Shaul, and Y. Cohen, Novel Phenanthroline-Containing Trinuclear Double-Stranded Helicates: Self- Recognition between Helicates with Phenanhtroline and Bipyridine Binding Sites. J. Org. Chem., 64, 9358-9364 (1999).
42. Y. Assaf, A. Holokovsky, E. Berman, Y. Shapira, E. Shohami, and Y. Cohen, Perfusion and Diffusion MRI Following Closed head Injury in the Rats. J. Neurotrauma, 16, 1165-1177 (1999).
41. L. Frish, S. E. Matthews, V. Bohmer, and Y. Cohen, A Pulsed Gradient Spin Echo NMR Study of Guest Encapsulation by Hydrogen- Bonded Tetraurea Calix[4]arene Dimers. J. Chem. Soc. Perkin 2, 669-671 (1999).
40. Y. Assaf, and Y. Cohen, Structural Information of Neuronal Tissues as Revealed from q-Space Diffusion NMR Spectroscopy of Metabolites in Bovine Optic Nerve. NMR in Biomedicine, 12, 335-344 (1999).
39. M. Greenwald, D.Wessely, I. Goldberg, and Y. Cohen, Bis(Bipyridine)-Phenanthroline Double-Stranded Helicate of the d10 Metals: Zinc (II), Silver (I) and Copper (I) Helicates. New J. Chem., 23, 337-344 (1999).
38. Y. Assaf, and Y. Cohen, Non Mono-Exponential Attenuation of the Water and N-Acetyl Aspartate Signals Due to Diffusion in Brain Tissue. J. Mag. Reson., 131, 69-85 (1998).
37. A. Gafni, Y. Cohen, S. Palmer, and D. Parker, NMR Studies of Enantiomer Discrimination Using Lipophilic Cyclodextrines: The Use of Pulsed-Gradient Method to Probe Chiral Differentiation. J. Chem. Soc. Perkin 2, 19-23 (1998).
36. Y. Assaf, and Y. Cohen, In Vitro and in in Vivo Bi-Exponential Diffusion of the N-Acetyl Aspartate (NAA) in Rat Brain: a Potential Structural Probe? NMR in Biomedicine, 11, 67-74 (1998).
35. M. Greenwald, M. Eassa, E. Katz, I. Willner, and Y. Cohen Electrochemical Characterization of a Self-Assembeled Double-Strand Copper Complex Composed of Three Cu+ and a Two Ligands Containing Bis(bipyridine) -Bithiophene Units. J. Electroanal. Chem., 434, 77-82 (1997).
34. Y. Assaf, E. Beit-Yanai, E. Berman, E. Shohami and Y. Cohen, Diffusion and T2-weighted MRI of Closed Head Injury in Rats: A Time Course Study and Correlation with Histology, Magn. Reson. Imaging, 15, 77-85 (1997).
33. Y. Assaf, G. Navon and Y. Cohen, In Vivo Observation of Anisotropic Motion of Brain Water Using 2H Double Quantum Filtered NMR Spectroscopy. Magn. Reson. Med., 37, 197-203, (1997).
32. A. Gafni, and Y. Cohen, Complexation of Macrocyclic Systems to g-Cyclodextrin (g-CD) as Obtained by NMR Diffusion Measurements. J. Org. Chem., 62, 120-125, (1997).
31. Y. Assaf, and Y. Cohen, Detection of Different Water Populations in Brain Tissue Using 2H Single- and Double-Quantum-Filtered Diffusion NMR Spectroscopy. J. Magn. Reson. B. 112, 151-159, (1996).
30. O. Mayzel, A. Gafni, and Y. Cohen, Water Hydration of Macrocyclic Systems in Organic Solvents: A NMR Diffusion and Chemical Shift Study. J. Chem. Soc. Chem. Comm. 911-912, (1996).
29. O. Mayzel, O. Aleksiuk, F. Grynszpan, S. E. Biali and Y. Cohen, NMR Diffusion Coefficients of p-tert-Butylcalix[n]arene Systems. J. Chem. Soc. Chem. Comm. 1183-1184, (1995).
28. Y. Cohen and A. Ayalon, Self-Diffusion of Charged Polycyclic Systems and Their Respective Parent Compounds: A PGSE NMR Study, Angew. Chem. Int. Ed. Engl. 34, 816-818 (1995).
27. O. Mayzel and Y. Cohen, Diffusion Coefficients of Macrocyclic Complexes Using the PGSE NMR Technique: Determination of Association Constants, J. Chem. Soc. Chem. Commun. 1901-1902, (1994).
26. L. Litt, Y. Xu, Y. Cohen, and T. L. James, Nonmagnetic Hyperbaric Chamber for In Vivo NMR Spectroscopy Studies of Small Animals, Magn. Reson. Med., 29, 812-816, (1993).
25. Y. Xu, Y. Cohen, L. Litt, L.-H. Chang and T. L. James, Tolerance of Low Cerebral Intracellular pH in Rats During Hyperbaric Hypercapnia, Stroke, 22, 1303-1308, (1991).
24. L.-H. Chang, Y. Cohen, P. R. Weinstein, L. Chileuitt, and T. L. James, Interleaved 1H and 31P Spectroscopic Imaging for Studying Regional Brain Ischemia, Magn. Reson. Imaging, 9, 223-227, (1991).
23. Y. Cohen, Y. Fraenkel, M. Rabinovitz, P. Felder, and F. Gerson, Segregation of Charge in Dibenzo [a,c] Naphthacene Ions: Relation of Topology and Electronic Structure, An NMR, ESR and ENDOR Study, Hel. Chim. Acta, 73, 2048-2057 (1990).
22. L. Litt. S. Lockhart, Y. Cohen, N. Yasuda, F. Kim, B. Freire, M. Laster, N. Peterson, S. Taheri, L.-H. Chang, D. I. Sessler, M. Moseley, E. I. Eger II, and T. L. James, In Vivo 19F NMR Brain Studies of Halothane, Isoflurane, and Desflurane: Rapid Elimination and No Abundant Saturable Binding, Annals New York Acad. Sci., 625, 707-724 (1991).
21. S. H. Lockhart, Y. Cohen, N. Yasuda, B. Freire, S. Taheri, L. Litt, E. I. Eger II, Cerebral Uptake and Elimination of Desflurane, Isoflurane, and Halothane From Rabbit Brain: An In Vivo NMR Study, Anesthesiology, 74, 575-580 (1991).
20. J. Mintorovitch, M. E. Moseley, L. Chileuitt, H. Shimizu, Y. Cohen, and P. R. Weinstein, Comparison of Diffusion- and T2-Weighted MRI for the Early Detection of Cerebral Ischemia and Reperfusion in Rats, Magn. Reson. Med., 18, 39-50 (1991).
19. Y. Cohen, T. Sanada, L.H. Pitts, L.-H. Chang, M. C. Nishimura, L. Litt, P. R. Weinstein, and T. L. James, Surface Coil Spectroscopic Imaging: Time and Spatial Evolution of Lactate Production Following Fluid Percussion Brain Injury, Magn. Reson. Med., 17, 225-236 (1991).
18. M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, Diffusion-Weighted MRI of Anisotropic Water Diffusion in Cat CNS, Radiology, 176, 439-445 (1990).
17. S. H. Lockhart, Y. Cohen, N. Yasuda, F. Kim, L. Litt, E. I. Eger II, L.-H. Chang, and T. L. James, Absence of Abundant Binding Sites for Anesthetics in Rabbit Brain: An in vivo NMR study, Anesthesiology, 73, 455-460 (1990
16. M. E. Moseley, J. Kucharczyk, J. Mintorovitch, Y. Cohen, J. Kurhanewicz, N. Deruglin, H. Asgari, and D. Norman, Diffusion-Weighted MR Imaging of Acute Stroke: Correlation with T2-weighted and Magnetic Susceptibility Enhanced MR Imaging in Cats, Am. J. Neuroradiology, 11, 423-429 (1990).
15. M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, Early Detection of Regional Cerebral Ischemia in Cats: Comparison of Diffusion- and T2-weighted MRI and Spectroscopy, Magn. Reson. Med. 14, 330-346 (1990).
14. Y. Cohen, L.-H. Chang, L. Litt, F. Kim, J. W. Severinghaus, P. R. Weinstein, R. L. Davis, I. Germano, and T. L. James, Stability of Brain Intracellular Lactate and 31P Metabolite Levels at Reduced Intracellular pH During Prolonged Hypercarbia in Rats, J. Cereb. Blood Flow Metab. 10, 277-284 (1990).
13. Y. Cohen, L.-H. Chang, L. Litt, and T. L. James, Spatially Localized COSY Spectra from a Surface Coil Using Phase-Encoding J. Magn. Reson., 85, 203-208 (1989).
12. M. Rabinovitz, and Y. Cohen, Probing The Nature of Polycyclic Conjugated Anions: From Carbocyclic to Heterocyclic Dianions: NMR Studies , p-Delocalization and Electronic Structure, Tetrahedron, 44, 6957-6994 (1988).
11. Y. Cohen, M. Rabinovitz, and J. Klein, The Charge Alternation Concept: Application to Cyclic Conjugated Doubly Charged Systems, J. Am. Chem. Soc. 110, 4634-4640 (1988)
10. Y. Cohen ,J. Klein, and M. Rabinovitz, 1,3-Diphenylbenzo[c]furan Dianion: NMR Characterization of a 4np Heterocyclic Dianion Containing Oxygen, J. Chem. Soc. Perkin Trans. 2, 31-38 (1988).
9. Y. Cohen, N. H. Roelofs, G. Reinhardt, L.T. Scott, and M. Rabinovitz, Novel Carbocyclic Dianions: NMR Study of Charge Delocalization, Paratropicity and Structure in the Dianions of Acephenanthrylene and Aceanthrylene, J. Org. Chem. 52, 4207-4214 (1987).
8. Y. Cohen, J. Klein, and M. Rabinovitz, New Heterocyclic Dianions: NMR Characterization of 1,3-Diphenylbenzo[c] thiophene Dianion: A Stable 4np Charged System Containing Sulphur, J. Chem. Soc. Chem. Commun. 1538-1540 (1987).
7. D. Tamarkin, Y. Cohen, and M. Rabinovitz, Ring Closure of Heterocyclic Systems by Potassium Graphite Intercalate-C8K, Synthesis 196-197 (1987).
6. Y. Cohen, A. Y. Meyer, and M. Rabinovitz, New Polyheterocyclic 4np Electron Dianions: Paratropicity, Charge Delocalization and Reaction. J. Am. Chem. Soc. 108, 7039-7044 (1986).
5. Y. Cohen, J. Klein, and M. Rabinovitz, Stable Polycyclic Anions: Dianions From Overcrowded Ethylene, J. Chem. Soc. Chem. Commun. 1071-1073 (1986).
4. M. Rabinovitz, Y. Cohen, and M. Halpern, Hydroxide Ion Initiated Reactions Under Phase Transfer Catalysis Conditions: Mechanism and Implications. Angew. Chem. Int. Ed. Engl. 25, 960-970 (1986).
3. Y. Cohen, J. Klein, and M. Rabinovitz, Novel Heterocyclic Anions: Benzo[b]thiophene Dianion, The First Sculpture Double Charged 4np System, J. Chem. Soc. Chem. Commun. 1033-1034 (1985).
2. A. Minsky, Y. Cohen, and M. Rabinovitz, Novel Polycyclic Dianions: Metal Reduction of Nitrogen Heterocycles. J. Am. Chem. Soc. 107, 1501-1504 (1985).
1. M. Halpern, Y. Cohen, Y. Sasson, and M. Rabinovitz, Hydroxide Ion Initiated Reactions Under Phase Transfer Catalysis Conditions 8: Notes on the Interfacial Mechanism, Nouveau J. Chim. 8, 443-444 (1984).

 

Book Chapters
9. Y. Cohen, Y. Assaf, Extraction of Geometrical Properties of White Matter from q-Space Diffusion MRI (QSI), in "Diffusion Tensor MRI" D. K. Jones (Ed.), Submitted.
8. Y. Assaf, Y. Cohen, Inferring Microstructural Information of White Matter from Diffusion MRI, in "Diffusion MRI", H. Johansen-Berg, T. E. J. Beherns (Eds.), Academic Press, 2009, pp. 127-146.
7. Y. Cohen, L. Avram, T. Evan-Salem, L. Frish, Diffusion NMR in Supramolecular Chemistry, in " Analytical Methods in Supramolecular Chemistry", (C. A. Schalley, Ed.), Wiley-VCH, 2006, pp. 163-219.
6. D. Ben-Bashat, L. Ben Sira, M. Graif, P. Pianka, T. Hendler, Y. Cohen, Y. Assaf, White Matter Maturation from Birth Through Adulthood: High b Value Diffusion Weighted Imaging Study. In Proceedings of the NATO Advanced Research Workshop on Psychiatric Neuroimaging, V. Ng, G. J. Barker, T. Hendler (Eds.), IOC Press, Amsterdam, Netherlands, pp. 39-43, 2003.
5. Y. Assaf, O. Mayzel-Oreg, A. Gigi, D. Ben-Bashat, M. Graif, A. D. Korczyn, T. Hendler, Y. Cohen, q-Space Diffusion Imaging in Dementia, in Proceedings of the NATO Advanced Research Workshop on Psychiatric Neuroimaging, V. Ng, G. J. Barker, T. Hendler (Eds.), IOC Press, Amsterdam, Netherlands, pp. 224-230, 2003.
4. Y. Cohen, Y Assaf, R. Nossin-Manor, I. E. Biton, Diffusion and q-Space Diffusion MRI: From Cerebral Ischemia to Multiple Sclerosis and Beyond. In “Blood Brain Barrier: Drug Delivery and Brain Pathology” D. Kobiler, S. Lustig, S. Shapira (Eds.), Kluwer Academic/Plenum Publishers, New York, 2001, pp. 123-145.
3. Y. Cohen, O. Mayzel, A. Gafni, M. Greenwald, D. Wessely, L. Frish and Y. Assaf, NMR Diffusion Measurements in Chemical and Biological Supramolecular Systems in "NMR in Supramolecular Chemistry", NATO ASI Series, M. Pons, Ed., Kluwer Academic Publishers, 1999, Vol. 526, 301-306.
2. L. Litt, M. T. Espanol, Y. Xu, Y. Cohen. L.-H. Chang, P. R. Weinstein, P. H. Chan, and T. L. James, Ex Vivo Multinuclear NMR Spectroscopy of Perfused, Respiring Rat Brain Slices: Model Studies of Hypoxia, Ischemia, and Excitotoxicity, in " Biological NMR Spectroscopy", J. L. Markly and S. J. Opella (Eds.), Oxford University Press. New York., pp. 340-357 (1997).
1. M. Rabinovitz, and Y. Cohen, NMR Studies on 4np Conjugated Polycyclic Anions: Relation of the Energy Gap Between the HOMO and the LUMO to Paratropicity and Electronic Structure, in “Polynuclear Aromatic Compounds”, L. B. Ebert Ed., American Chemical Society, Washington, DC. Advances in chemistry series, 217, 53-72 (1988).

 

Patent and Edited Volumes

1. Y. Cohen, Y. Assaf, Imaging of Neuronal Material. US patent application No. 09/661,563 submitted 14 September 2000. Patent No.: US 6,529,763 B1 March 4, 2003.
2. Y. Cohen, and M. Neeman (Guest Editors). Diffusion NMR and MRI: Basic Concepts and Applications. Israel J. Chem. 43, 1-165 (2003).

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Last updated: 05/02/11.